1Tang DC,Devit M,Johnston SA.Genetic immunization is a simple method for eliciting an immune response[J].Nature,1992,356(6 365):152~154.
2Cohen AD,Biyer JD,Weiner DB.Modulating the immune response to genetic immunization[J].FASEB J,1998,12(15):1 611~1 626.
3Chu RS,Targoni OS,Krieg AM,et al.CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity[J].J Exp Med,1997,186(10):1 623~1 631.
4Lisl KMS,Kimberly AK,Carlos ES,et al.DNA from protozoan parasite babesia bovis, trypanosoma cruzi,and T.brucei is mitogenic for B lymphocytes and stimulates macrophage expression of interleukin-12, tumor necrosis factor alpha, and nitric oxide[J].Infect and immun,2001,69(4):2 162~2 171.
5Sparwasser T,Miethke T,Lipford G,et al.Bacterial DNA causes septic shock[J].Nature,1997,386(6 623):336~337.
6Rice J,Elliott T,Buchan S,et al.DNA fusion vaccine designed to induce cytotoxic T cell responses against defined peptide motifs:implications for cancer vaccines[J].J Immunol,2001,167(3):1 558~1 586.
7Chance JH,Hooker NK,Mildenstein KL,et al.Bacterial DN A-induced NK cell INF-γ production in dependent on macrophage secretion of IL-12[J].Clin Immunol Immunopathol,1997,84(2):185~193.
8Krieg AM,Yi AK,Mason S,et al.CpG motifs in bacterial DNA trigger direct B-cell activation[J].Nature,1995,374(6 522):546~549.
9Crabtree TD, Jin L,Raymond DP,et al.Preexposure of murine macrophages to CpG oligonucleotide results in a biphasic tumor necrosis factor alpha response to subseququent lipopolysaccharide challenge[J].Infect and Immun,2001,69(4):2 123~2 129.
10Haker H,Mischak H,Hacker G,et al.Cell type-speific activation of mitogen-activated protein kinase by CpG-DNA controls interleukin-12 release from antigen-presenting cells[J].EMBO J,1999,18(2):6 973~6 982.
二级参考文献21
1[1]Sato Y, Roman M, Tighe H, et al. Immunostimulatory DNA se quences necessary for effective intradermal gene immunization. Science, 1996,273 ( 19 ): 352
2[2]Broide D, Schwarze J, Tighe H, et al. Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperres-ponsiveness in mice. J Immunol, 1998,161 (12) :7054
3[3]Klinman DM. CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 12 and interferon-γ. Proc Natl Acad Sci USA, 1996,93: 2879
4[4]Kline JN, Waldschmidt TJ, Businga TR, et al. Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. J Immunol, 1998,160(6) :2555
5[5]Corry D, Folkesson HG, Warnock M, et al. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J Exp Med , 1996,183:109
6[6]Walker C,Bode E,Boer L, et al. Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokines production in peripheral blood and bronchoalveolar lavage. Am Rev Respir Dis, 1992,146:109
7[7]Drazen JM, Ann JP, Austen KF, et al. Sorting out the cytokines of asthma. J Exp Med, 1996,183:1
8[8]Broide D, Raz E. DNA-based immunization for asthma. Imt Arch Allergy lmmunol , 1999,118: 453
9[9]Spiegelberg HL,Tighe H, Roman M, et al. Inhibition of IgE formation and allergic inflammation by allergen gene imxunization and by CpG motif immunostimulatory oligodeoxynucleotides. Allergy, 1998,53: 93
10[10]Raz E,Tighe H, Sato Y, et al. Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization. Proc Natl Acad Sci USA, 1996,93:5141