摘要
目的探讨壮、汉族甲状腺功能亢进症(甲亢)患者血浆内皮素(Endotheliolysin,ET)和一氧化氮(nitrogen monoxide,NO)水平变化及临床意义。方法用放射免疫法、比色法和化学发光法分别测定了壮族甲亢患者66例、汉族甲亢患者52例的血浆ET、NO和甲状腺激素(TH),同时设立50例壮族健康对照组,将3组结果进行比较。结果壮、汉两民族甲亢患者血浆ET显著高于正常对照组(38.69±14.13)pmol/L和(41.06±13.29)pmol/Lvs(18.56±6.71)pmol/L(P<0.01),并与TH含量呈正相关(均P<0.01),而血浆NO含量则低于正常对照组(63.52±10.16)μmol/L和(61.48±9.18)μmol/Lvs(78.46±12.38)μmol/L(P<0.01),与TH呈负相关(均P<0.01)。两组甲亢患者的ET与NO含量呈负相关(均P<0.01)。但壮、汉族甲亢患者的血浆ET、NO含量比较差异无统计学学意义(P>0.05)。结论甲亢患者血浆ET和NO水平的变化不存在壮、汉族民族间的差异,血浆ET、NO的变化参与甲亢的病理生理过程。
Objective To investigate the changes of plasma endotheliolysin（ET） and nitrogen monoxide（NO） between Zhuang ethnic and Han ethnic hyperthyroidism patients. Methods Determination of ET,NO,thyroid hormone （TH） in sixty-six cases of Zhuang ethnic and fifty-two cases of Han ethnic hyperthyroidsm patients were determined by radioimmunoassay（RIA）, colorimetric method and chemiluminescence. Fifty cases of Zhuang ethnic healthy people served as control group. Results ET in both ethnic patient groups （38.69 ± 14.13） pmol/L and （41.06±13.29） pmol/L was notably higher than that in control group（18.56±6.71） pmol/L （ P 〈0.01）, and it was associated with TH（all P 〈0.01）. But NO in former groups （63.52±10. 16） μmol/L and （61.48±9.81）μmol/L was lower than that in control group （78. 46±12.38）μmol/L（ P 〈0.01）, and it was associated negatively with TH（all P 〈0.01）. But plasma ET and NO showed no significant differences between the two ethnic patient groups. Conclusion ET and NO did not have significant differences between two ethnic patients. Changes of ET and NO joined in the pathological process of hyperthyroidism.
出处
《临床荟萃》
CAS
北大核心
2005年第21期1216-1218,共3页
Clinical Focus
