摘要
目的研究Survivin在宫颈鳞癌组织中的表达及其意义。方法采用免疫组化S-P法对53例不同分化程度的鳞癌组织及10例慢性宫颈炎组织进行Survivin检测。结果10例慢性宫颈炎组织中未发现Survivin阳性表达,53例宫颈鳞癌中Survivin阳性表达率为54.7%(29/53),阳性表达的Survivin主要定位于肿瘤组织的细胞浆,偶见于细胞核。结论宫颈鳞癌组Survivin阳性表达显著高于慢性宫颈炎组,并与宫颈鳞癌的分化程度有关,提示Survivin参与了宫颈癌的发生和发展过程。
Objective To study the expression and significance of survivin in cervical squamous cell carcinoma. Methods S-P immunohistochemical method was adopted to examine the expression of survivin in 53 specimens of cervical squamous cell carcinoma and in 10 specimens of chronic cervicitis. Results Expressions of survivin in chronic cervicitis were negative. The positivity rate of survivin expressions in cervical squamous cell carcinoma was 54.7 % （29/53）. The positive expression of survivin mainly located in cell cytoplasm, fewer in nucleus. Conclusion The positive expression of survivin in ceivical squamous cell carcinoma group is higher than that in the chronic civicitis group and positive expressions of survivin in cervical squamous cell carcinoma relate to the degree of differentiation. The results suggest the survivin may participate in developing and progressing in squamous cell carcinoma of cervix.
出处
《苏州大学学报（医学版）》
CAS
北大核心
2005年第5期875-876,共2页
Suzhou University Journal of Medical Science
