摘要
目的:探讨低剂量奥氮平联合氟伏沙明治疗精神分裂症的临床疗效.方法:选择48例精神分裂症患者,随机分成两组,分别给予高剂量奥氮平(15～20mg/d)为对照组和低剂量奥氮平(5～10mg/d)联合氟伏沙明(50mg/d)为研究组,治疗8周.在第1、2、4、8周末进行BPRS及因子分、TESS分的评定,以了解临床疗效及副反应.结果:对照组临床疗效87.5%显效;研究组79.2%.BPRS因子分中,焦虑抑郁分的降低两组比较有显著差异.结论:氟伏沙明可增强奥氮平疗效,并改善精神分裂症伴有的焦虑抑郁症状.
Objective： To study the efficacy of little dosage Olanzapine combined with Fluvoxamine in treatment of schizophrenia. Methods.48 patients with schizophrenia were randomly assigned to two groups. Olanzapine combined with Fluvoxamine （the study group） of 24 patients was treated with 5 - 10mg/D Olanzapine and 50mg/D Fluvoxamine. Another was treated with 15 -20mg/D Olanzapine. The duration of treatment was 8 weeks. The brief psychiatric rating scale （BPRS） and treatment emergent symptom scale （TESS） were used to measure the efficacy and side effects. Results： Effects of two groups were similar in treatment and there were no serious side effects. The improvement rate of clinical was 79.2% in study group and 87.5% in another. The factor of Anxiety/Depression in BPRS was significant differences between the two groups. Conclusions： Fluvoxamine can improve the efficaey to Olanzapine and ameliorate symptoms of anxiety and depression in schizophrenia.
出处
《中国民康医学》
2005年第10期573-574,共2页
Medical Journal of Chinese People’s Health
