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前列泰胶囊中盐酸水苏碱含量的HPLC研究 被引量:2

Determination of Stachydrine Hydrochloride Content in Qianlietai Capsule by HPLC
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摘要 [目的]建立用高效液相色谱法(HPLC)测定前列泰胶囊中盐酸水苏碱含量的方法。[方法]采用磺酸基团键合硅胶(SCX)的阳离子交换色谱柱(4.6×250mm,5μm),流动相:0.05molL/磷酸二氢钾-三乙胺(100∶0.1)(以磷酸调pH值至2.3),流速:1.0mLm/in,检测波长:192nm,柱温:30℃,进样量:20μL。[结果]线性范围:4.104~12.312μg,r=0.9999。平均回收率:98.5%,RSD=1.64%(n=5)。[结论]本法分离度好,适用于前列泰胶囊中盐酸水苏碱的含量测定,可作为产品的质量控制方法。 [Objective] To establish a method for determination of the stachydrine hydrochloride in Qianlietai capsule by HPLC. [Methods] The cationic exchange chromatographic column of sulfonie group bonded silica gel(SCX) was used(4.6×250 mm, 5 μm). The mobile phase was composed of 0.05 mol/L KH2PO4-(C2H5)3N (100:0.1) (pH23). Detection wavelength was at 192 nm, the flow rate was 1.0 mL/min, column temperature was at 30 ℃, the injection volume was 20μL. [Result] The linear response range was at the 4.104-12.312 μg, r=0.999 9. The recovery rate was 98.5% and RSD was 1.64%(n=5). [Conclusion] The HPLC method may act as the method of product quality control and own good resolving power. The HPLC method was suitable for the determination of stachydrine hydrochloride content in Qianlietai capsule.
出处 《天津中医药》 CAS 2005年第5期425-427,共3页 Tianjin Journal of Traditional Chinese Medicine
关键词 HPLC 前列泰胶囊 盐酸水苏碱 HPLC Qianlietai capsule stachydrine hydrochloride
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