摘要
目的研究芪丹合剂对高脂血症大鼠血浆的作用。方法采用喂食高脂饲料方法复制大鼠高脂血症模型,以复方丹参片为对照,检测各组大鼠血浆的内皮素(ET)和降钙素基因相关肽(CG RP)含量。结果用药各组在50d后,上述两指标与模型组相比均有不同程度改善,高剂量组最为明显(P<0.01)。用药80d后,上述差异更加显著。结论芪丹合剂可以降低高脂血症大鼠血浆中ET含量,升高CGRP含量,具有血管内皮保护作用。
Objective To observe the effect of QIDAN Misture （QDM）on the ET and CGRP in the blood plasma of hyperlipidemic rats. Methods Feeding the rats with high-lipid forage to duplicate the model of hyperlipidemia, then examining the content of ET and CGRP in plasma of each group, comparing with Composite Salviae tablets as the control medicine were performed.Results The data in therapy groups improved differently after applying medicine for 50 days. The high dose group was more significant than others （P〈0.01）. The improvements were much more on 80th day.Conclusion By decreasing the content of ET and increasing the content of CGBP in plasma, QIDAN Misture can decrease the injury of vessel endothelial cell.
出处
《实用医药杂志》
2005年第10期911-912,共2页
Practical Journal of Medicine & Pharmacy
关键词
芪丹合剂
黄芪
丹参
高脂血症
内皮素
降钙素基因相关肽
QIDAN Misture（QDM） Astragalus membranaceus Salviae miltorrhizae Hyperlipidemia Endothlin （ET） Calcitonin gene-related peptide（CGRP）
