摘要
目的:对芍药甘草滴丸的抗炎镇痛作用进行初步研究。方法:采用二甲苯致小鼠耳肿胀、蛋清致大鼠足肿、热板法、冰醋酸扭体法。结果:芍药甘草滴丸18.75、37.5、75g/kg.d-1,汤剂组18.75g/kg.d-1均明显减轻二甲苯所致小鼠炎症(P<0.01);芍药甘草滴丸9.375、18.75、37.5g/kg.d-1的大鼠足跖肿胀率低于对照组(P<0.01,P<0.05);芍药甘草滴丸18.75、37.5、75g/kg.d-1,汤剂组18.75g/kg.d-1均能显著延长小鼠热板法的痛阈值(P<0.01);芍药甘草滴丸37.5、75g/kg.d-1,汤剂组18.75g/kg.d-1均对冰醋酸所致小鼠扭体反应次数显著减少(P<0.01,P<0.05)。结论:芍药甘草滴丸具有抗炎、镇痛作用。
Objective:to study the anti-inflammatory and abirritative action of Shaoyaogancao Dripping Pills. Methods: Xylenewas used to swell the rat's ears, albumento make feet turgescent, and methods of hot plateand swiveling by glacial acetic acidwere also applied. Results: both Shaoyaogancao Pills 18.75、37.5、75 g / kg.d -1 and decoctiongroup 18.75 g / kg.d -1 relieved the inflammation of induced by Xylene(P<0.01); volaswelling rate of the Pills 9.375、18.75、37.5 g / kg.d -1was lower than that of control group(P<0.01, P<0.05);both the Pills 18.75、37.5、75 g/kg.d -1 and decoction group 18.75g / kg.d -1 prolonged the threshold of pain(P<0.01); both the Pills 37.5、75 g / kg.d -1 and decoction group 18.75 g / kg.d -1 made rats lessen the swiveling induced by glacial acetic acid (P<0.01, P<0.05). Conclusion: Shaoyaogancao Dripping Pills have the action of anti-inflammationandabirritation.
出处
《河北中医药学报》
2005年第3期3-5,共3页
Journal of Hebei Traditional Chinese Medicine and Pharmacology
基金
河北省卫生厅资助项目:2001005
关键词
芍药甘草滴丸
芍药甘草汤
抗炎
镇痛
Shaoyaogancao Dripping Pills
Shaoyaogancao decoction
anti-inflammatory
abirritative
