摘要
[目的]探讨甲醛对大鼠子代早期神经行为发育的影响。[方法]进行两代一窝繁殖试验,选用体重110-130 g Wistar大鼠120只,随机分为4组,染毒浓度分别为,高浓度组:(119.6±15.4)mg/m3、中浓度组:(25.2±4.6)mg/m3、低浓度组:(4.8±1.3)mg/m3、对照组:室内空气。采用静式吸入法,每天染毒1 h,雄鼠连续染毒至交配后,雌鼠连续染毒至子代断乳,用一组行为毒理学方法检测雌、雄大鼠暴露于甲醛后子代生理及神经行为发育的情况。[结果]随着染毒浓度的增加,F1、F2代大鼠张耳、门齿萌出和开眼3项反映早期生理发育指标和平面翻正反射和悬崖回避试验阳性率呈逐渐降低趋势(P<0.05),学习、记忆达标训练次数和达标时间明显增多和延长(P<0.05),高浓度组学习达标时间、记忆达标时间分别高达(307.0±49.5)s、(279.7±42.35)s,持续游泳时间及耐缺氧时间均逐渐缩短,分别为(31.63±7.50)min、(43.40±4.94)min,P<0.05。[结论]甲醛对子代大鼠的神经系统有明显的损害作用。
[ Objective ] In order to explore the effects of formaldehyde exposure on the earlier neurobehavioral development of rat offsprings. [ Methods ] A two generations-one nest reproductive test was used . 120 Wistar rats weighted 110-130 g were randomly divided into 4 groups： the high concentration group at 119.6±15.4 mg/m^3, the middle concentration group at 25.2 ± 4.6 mg/m^3, the low concentration group at 4.8 ± 1.3 mg/m^3 and the control group exposed to indoor air.The male and female rats inhaled formaldehyde for lh everyday, the male rats inhaled until mating, and the female rats inhaled until weaning, the indexes of earlier neurobehavloral development of offsprings were measured. [ Results ] The results demonstrated that with increasing concentrations of formaldehyde, the positive rates of early physiological development and nerve reflect indexes decreased obviously （ P 〈 0.05 ）, and the abilities of learning and memory of the offsprings decreased （ P 〈 0.05 ）, the learning and memory training time for high concentration group were 307.0 ± 49.5 and 279.7 ± 42.35 sec, the swimming time and enduring anoxia time gradually shortened （ P 〈 0.05 ）, they were 31.63 ± 7.50 and 43.40 ± 4.94 min, respectively. [ Conclusion ] Formaldehyde displays distinct damage to the nerve system of the offsprings.
出处
《环境与职业医学》
CAS
北大核心
2005年第5期426-428,共3页
Journal of Environmental and Occupational Medicine
关键词
甲醛
子代
神经行为
大鼠
formaldehyde
offspring
neurobehavior
rat
