摘要
目的探讨介入化疗治疗浸润性膀胱癌的临床疗效.方法收集整理中山大学附属第一医院和肿瘤防治中心于2001年3月～2003年12月间确诊为浸润性膀胱癌的21例患者接受介入化疗的临床资料.用MVCA的改进方案化疗1～5个疗程并予对症、支持治疗.其中6例采用经股动脉穿刺皮下埋置PCS药泵介入化疗法;15例采用经股动脉穿刺、髂动脉置管介入化疗法.结果随访3～33个月,18例患者皆生存至今,3例死于肿瘤进展,2例患者达到肿瘤降级,8例肿瘤降期.完全缓解3例,部分缓解6例,好转6例,稳定6例.结论经动脉介入化疗是浸润性膀胱癌的有效治疗方法之一,可使肿瘤降期、降级,改善生存质量并延长生存期.
[Objective] To explore the clinical therapy effect of intraarterial chemotherapy for patients with invasive bladder cancer. [Methods] Clinical data of 21 case with invasive bladder cancer treated at the First Affiliated Hospital and Cancer Center of Sun Yat-sen University, between March 200l and November 2003, with intra-aterial chemotherapy, was analyzed retrospectively. Moditied MVAC （methotrexate, vinblastine, doxorubicin, and cisplatin） was used for the patients. The patients received 1 to 5 courses of intra-aterial chemotherapy intra-aterial chemotherapy. Intra-arterial chemotherapy was carried out through the port-catheter system in 6 patients, through iliae artery in 15 patients. [Results] The follow-up was 3-33 months. Eighteen patients were alive and 3 patients were died of carcinoma progression. Tumor downgrade was noticed in 2 cases and downstage in 7 cases. Of the 21 patients, 3 achieved complete regression, 6 achieved partial regression, 6 achieved minor regression and 6 stable disease. [Conclusion] Intra-arterial infusion chemotherapy was one of effective therapy of invasive bladder cancer. It could downgrade and downstage the tumors and improve the survive and life quality of patients.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2005年第19期2988-2991,共4页
China Journal of Modern Medicine
关键词
膀胱癌
动脉内灌注
化疗
bladder cancer
intraarterial infusion
chemotherapy
