摘要
目的探讨乌司他丁对内镜逆行胰胆管造影(ERCP)术后高淀粉酶血症及急性胰腺炎的预防作用。方法将40例患者随机分为乌司他丁组和对照组。乌司他丁组造影前1h静滴乌司他丁2×105U,对照组静滴生理盐水250mL,观察术前和术后6h及24h血清淀粉酶的变化。结果乌司他丁组有3例和对照组有10例发生高淀粉酶血症,两组差异有统计学意义(P<0.05);乌司他丁组没有发生急性胰腺炎病例,对照组有2例发生急性胰腺炎,两组差异有统计学意义(P<0.05)。结论乌司他丁能有效地预防ERCP术后因胰管造影所致的高淀粉酶血症及急性胰腺炎。
Objective To investigate the preventive effects of ulinastatin on post endoscopic retrograde cholangiopancreatography（ERCP） hyperamylasemia and acute pancreatitis. Methods Forty patients were divided into 2＇ groups randomly, and ulinastatin of 2×10^5U was given to group A（n=20） by i.v. 1 h before ERCP while saline of 250 mL was given to group B（n=20） as control. Serum amylase was measured before ERCP, 6 h and 24 h after ERCP. Results Post ERCP hyperamylasemia occurred in 3 patients from group A（15%） and 10 from group B（50%）, and there was a significant difference between these two groups（P〈0.05）. Two cases from group B were suffered from acute pancreatitis（10%）, but no cases from group A were suffered from it. The difference was also significant（P〈0.05）. Conclusion Ulinastatin can effectively prevent post ERCP hyperamylasemia and acute pancreatitis.
出处
《兰州大学学报（医学版）》
CAS
2005年第3期24-25,40,共3页
Journal of Lanzhou University（Medical Sciences）
