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Sam68及其在肿瘤形成中的作用 被引量：1

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摘要 Sam68是一种细胞内信号转导及RNA激活蛋白,通过自身的多个功能性模体与RNA,Src激酶家族及其他多种细胞内信号分子相作用。它作为细胞信号转导过程中的衔接蛋白参与细胞周期的调控,与细胞增殖和凋亡密切相关。其表达异常可导致细胞的恶性转化。
作者 郭恩琪 综述 吴育连 审校
机构地区 浙江大学医学院附属第二医院外二科
出处 《国际病理科学与临床杂志》 CAS 2005年第4期324-327,共4页 Journal of International Pathology and Clinical Medicine
关键词 Sam68 KH结构域 Src蛋白酪氨酸激酶 细胞增殖和凋亡
分类号 R730.2 [医药卫生—肿瘤]
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参考文献23

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同被引文献24

  • 1Lee AW,Foo W,Law SC. Staging of nasopharyngeal carcinoma:From Hos to the new UICC system[J].International Journal of Cancer,1999,(02):179-187.
  • 2Nathanson SD. Insights into the mechanisms of lymph node metastasis[J].Cancer,2003,(2):413-423.doi:10.1002/cncr.11464.
  • 3Richard S,Vogel G,Huot ME. Sam68 haploinsufficiency delays onset of mammary tumorigenesis and metastasis[J].Oncogene,2008,(04):548-556.
  • 4Song L,Wang L,Li Y. Sam68 up-regulation correlates with,and its down-regulation inhibits,proliferation and tumourigenicity of breast cancer cells[J].Journal of Pathology,2010,(03):227-237.
  • 5Li Z,Yu CP,Zhong Y. Sam68 expression and cytoplasmic localization is correlated with lymph node metastasis as well as prognosis in patients with early-stage cervical cancer[J].Annals of Oncology,2012,(03):638-646.
  • 6Busà R,Paronetto MP,Farini D. The RNA-binding protein Sam68 contributes to proliferation and survival of human prostate cancer cells[J].Oncogene,2007,(30):4372-4382.doi:10.1038/sj.onc.1210224.
  • 7Zhang Z,Li J,Zheng H. Expression and cytoplasmic localization of SAM68 is a significant and independent prognostic marker for renal cell carcinoma[J].Cancer Epidemiology Biomarkers and Prevention,2009.2685-2693.
  • 8Chin D,Boyle GM,Porceddu S. Head and neck cancer:Past,present and future[J].Expert Review of Anticancer Therapy,2006,(7):1111-1118.doi:10.1586/14737140.6.7.1111.
  • 9Yu MM,Yuan JM. Epidemiology of nasopharygeal carcinoma[J].Seminars in Cancer Biology,2002,(06):421.
  • 10Spano JP,Busson P,Atlan D. Nasopharyngeal carcinomas:an update[J].European Journal of Cancer,2003,(15):2121-2135.

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国际病理科学与临床杂志
2005年 第4期

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