期刊文献+

胃间质瘤67例预后分析 被引量:9

The prognostic factor of Gastric Stromal Tumor:a study of 67 patients.
原文传递
导出
摘要 目的探讨胃间质瘤的预后.方法回顾性分析1994~2004年67例胃间质瘤临床病理资料,以新的间质瘤分级法Flecther分级.采用kaplan-meier法绘制生存曲线(log-rank检验)和cox多因素回归分析对该组病例预后分析.结果根据Flecther风险分级,极低风险 5例(7.5%),低风险11例(16.4%),中风险29 例(43.3%),高风险22例(32.8%),术后生存率随分级依次递减 (P=0.0001),比较肿瘤大小,核分裂相(>5,≤5),是否伴发远处转移,是否伴发淋巴结转移差异具有显著性(P<0.05),根治性手术与非根治性手术组比较差异具有显著性(P=0.04).而肿瘤位置、年龄、性别、免疫组化表达情况、是否联合脏器切除差异无显著性.结论用Flecther分级对胃间质瘤分级评价更为科学合理.根治性手术是治疗胃间质瘤最佳选择,核分裂相是判断预后的独立预后因素. Objective To investigate the prognostic factor of Gastric Stromal Tumors. Methods The clinicopathological data of opratod 67 patients with Gastric Stromal Tumors were analyzed restrospectively. Tumors were divided in risk classes using a new classification proposed by Flecther. kalian-meier survival rate curve and cox regression model were used to evaluate the prognostic factor. Results Using Flecther s classification, tumors were divided in very low risk ( 5/67, 7.5% ) ,low risk ( 11/67,16.4% ) , intermediate risk ( 29/67,43.3% ) , high risk ( 22/67,32.8% ). The survival rate were gradually decreased from very low risk, low risk, intermediate, high risk (P=0.0001). Tumor size, mitosis, distant metastases, lymph node metastases were analyzed respectively, the difference is statistical significance ( P〈0.05 ). Compare complete surgical excision with incomplete excision, there is significant difference between this two group (P=0.04). No significant difference between the group of tumor location, age, sex, immunohistochemical expression, multi-organ excision or not. Conclusion Flecther s classification is scientific and rational. Complete surgical excision of the Gastric Stromal Tumors is the best chance of cure. Mitotic rate is an independent factor that may predict the prognosis of Gastric Stromal Tumors.
出处 《中国实用外科杂志》 CSCD 北大核心 2005年第10期625-627,共3页 Chinese Journal of Practical Surgery
关键词 胃间质瘤 Flecther分级 淋巴结转移 Gastric stromal tumor Hlecther classification Lymph node metastasis
  • 相关文献

参考文献10

  • 1Miettinen M,Lassota J.Gastrointestinal stromal tumors definition,clinical,histolgical,immunohistochemical,and molecular genetic features and differential diagnosis.Virchows Arch,2001,438(1):1-12.
  • 2Miettinen M,JY Blay,LH Sobin. Mesenchymal tumors of the stomach.WHO classification of tumors.Pathology and genetics of tumors of digestive system.Lyon:IARC Press,2002.62-65.
  • 3DeMatteo RP,Lewis JL,Leung,et al.Gastrointestinal stromal tumors: recurrence patterns and prognostic factors survival.Ann Surg,2000,231(1):51-58.
  • 4Ihor Pidhorecky MD,Richard T,Cheney,MD,et al.Gastrointestinal Stromal Tumors:Current Diagnosis,Biologic Behavior,and Management.Ann Surg Oncol,2000,7(9):705-712.
  • 5Flecther CD,Berman JJ,Corless C,et al.Diagnosis of gastrointestinal stromal tumors:a consensus approach.Hum Pathol,2002,33(5):459-465.
  • 6Lau S,Tam KF,Kam CK,et al.Imaging of gastrointestinal stromal tumor.Clin Radiol,2004,59(1):487-498.
  • 7Besana-Ciani I,Boni L,Dionigi G,et al.Outcome and long term result of surgical resection for gastrointestinalstromaltumors.Scand J Surg,2003,92(3):195-199.
  • 8Crosby JA,Catton CN,Davis A,et al,Malignant gastrointestinal stromal tumors of the small intestine:a review of 50 cases from a prospective database.Ann Surg Oncol,2001,8(1):50-59.
  • 9Ronald P.DeMatteo MD.The GIST of Targeted Cancer Therapy:A Tumor(Gastrointestinal Stromal Tumor),a Mutated Gene(c-kit),and a MolecularInhibitor(STI571).Ann Surg Oncol,2002,9(9):831-839.
  • 10Blanks CD.Therapeutic options for gastrointestinal stromal tumors.Proc ASCO,2003.266-272.

同被引文献85

引证文献9

二级引证文献18

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部