摘要
目的:探讨癫痫大鼠发作前后脑内免疫状态和经免疫球蛋白(IVIg)干预处理后其肿瘤坏死因子-α(TNF-α)和白细胞介素-2、4、10(IL-2、4、10)等细胞炎性因子的变化。方法:用印防已毒素(PTX)制备癫痫大鼠模型,在发作前、后分别给予IVIg进行干预处理,检测脑组织匀浆内TNF-α和IL-2、4、10的浓度变化,并与对照组比较。结果:癫痫大鼠发作后其脑内TNF-α和IL-2、IL-4、IL-10的水平显著升高,给予IVIg干预后,这4项炎性细胞因子水平明显低于模型对照组(P<0.01)。结论:癫痫大鼠发作后脑内某些与免疫反应相关的炎性细胞因子水平升高,而IVIg则能降低大鼠脑内免疫反应强度,从而抑制大鼠的癫痫发作。
Objective： To investigate the effect of immunoglobulin on epilepsy rat with detecting the content of intracerebral TNF-ct and interleukins-2,4 and 10. Methods： Prepared the epilepsy model of rat with picrotoxin （PTX） injection, then it was interfere the model with immunoglobulin injection either before or after seizure respectively. The content of intracerebral TNF-α and interleukins-2,IL-4 and IL-10 in experimental group were detected, and compared with those of control group. Results： The contents of TNF-α and interleukins-2,IL-4 and IL-10 were significantly increased after seizure. After interfered with immunoglobulin, they were significantly lower than those of the control group. Conclusion： The contents of TNF-α and interleukins-2, IL-4 and IL-10 significantly increase after seizure, and the immunoreaction can be decreased by immunoglobulin injection, consequently the seizure of epilepsy rat is controlled.
出处
《山东大学学报（医学版）》
CAS
北大核心
2005年第9期827-829,共3页
Journal of Shandong University:Health Sciences
基金
山东省卫生厅科研基金资助课题(2003CA1CJA5)
