摘要
目的探讨抗环瓜氨酸肽(CCP)抗体检测对幼年特发性关节炎(JIA)的诊断价值。方法用酶联免疫吸附试验(ELISA)对22例JIA患儿(男9例,女13例)、30例成人类风湿关节炎(RA)患者血清抗CCP抗体、RF进行检测,了解抗CCP抗体在JIA中的诊断价值。结果JIA患儿22例中2例抗CCP抗体阳性,阳性率为9.1%(2/22),显著低于成人RA组阳性率53.3%(16/30),P<0.01;JIA患儿与健康对照组(无CCP抗体阳性)抗CCP抗体阳性率尤差别,P>0.05。结论抗CCP抗体可在JIA中检测到,但阳性率很低,作为JIA诊断指标具有一定的局限性。
Objective To assess the clinical significance of antibodies against cyclic citrullinated peptide（anti - CCP） in a cohort of patients with juvenile idiopathic arthritis（JIA）. Methods The anti - CCP was tested by an enzyme linked immunosorbent assay （ELISA） in serum samples from 22 patients with JIA（9 boys, 13 girls）, with a mean age of 9.1 years（range 1.1 - 16）. As control groups, anti - CCP were also tested in sera of 20 healthy children, and 30 adult patients with rheumatoid arthritis（RA）. Results Positive and - CCP were found in sera of 2 patients with JIA（9.1% ）, both with lower titre comparing with those of adult patients with anti- CCP positivo. In the control groups, none of healthy children was positive for anti- CCP, but 16/30（53.3% ） adults with RA showed anti - CCP positivity. Conclusion Anti - CCP can be detected in children with JIA, but are less frequently present than in adults with RA, so anti - CCP has limited diagnostic value to JIA.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2005年第11期1084-1085,共2页
Journal of Applied Clinical Pediatrics
关键词
关节炎
关节炎
类风湿
抗环瓜氨酸肽抗体
arthritis
arthritis rheumatoid
antibodies against cyclic citrullinated peptide
