摘要
目的了解燃煤型砷中毒患者红细胞(RBC)免疫功能与脂质过氧化关系。方法将燃煤型砷中毒患者分为轻、中、重3组,选择距病区12km外的非燃用砷煤居民作对照组,分别检测各组RBC免疫功能和血浆MDA、SOD、GSH鄄Px,并分别与对照组比较。结果燃煤型砷中毒患者RBC免疫功能损伤RBC鄄ICR高于对照组,RBC鄄C3bRR低于对照组,患者MDA高于对照组,而SOD、GSH鄄Px则低于对照组。结论氧化自由基堆积造成脂质过氧化损伤,这可能是患者RBC免疫功能受损的重要原因。
Objective To study the relationship between RBC immunity and lipid peroxidation of arsenism patient. Methods The activity of superoxide dismutase （SOD）, glutsthione peroxidase （GSH-Px）, malondial dehyde （MDA）, RBC-ICR and RBC-C3bRR in the blood of patients were measured and analysed. Results Compared with those of the control, the SOD, GSH-Px and RBC-C3b RR levels were lower （P 〈 0.05）, while the MDA and RBC-ICR levels were higher （P 〈 0.05）. Conclusions It is suggested that lipid peroxidation might be one of the reasons causing RBC immunity damage.
出处
《中国地方病学杂志》
CAS
CSCD
北大核心
2004年第1期16-17,共2页
Chinese Jouranl of Endemiology
基金
国家自然科学基金资助项目(30060077)
关键词
砷中毒
红细胞
免疫功能
脂质过氧化
谷胱甘肽过氧化物酶
Arsenism patient
Red cell
Mmuuity malondisldohyde
Superoxide dismutase
Glutathione peroxidase
