摘要
目的了解燃煤型砷中毒患者血清中9种物质水平,并探讨其临床意义。方法应用放免测定法(RIA)对患者血清叶酸、VB12、胆酸(CG)、白细胞介素素鄄2(IL鄄2)、肿瘤坏死因子(TNF)、透明质酸(HA)、Ⅳ型胶原(IV.C)、转化生长因子鄄α(TGFα)、皮质醇进行测定和分析。结果砷中毒组与对照组比较,叶酸、VB12、IL鄄2、TNF明显下降(P< 0.01),CG、HA、IV.C、TGFα明显升高(P< 0.01);皮质醇整体与对照组比较,差异无显著意义(P> 0.05);分层分析,重度组与对照组比较,差异有显著意义(P< 0.01)。结论用放免方法检测燃煤型砷中毒患者血清中上述9中物质,可以了解砷对机体的损害程度和范围,对砷中毒的临床治疗具有重要的指导作用。
Objective To detect the serum levels of nine materials in patients suffered from coal type arsenic poisoning , so as to understand their clinical significance. Methods Serum contents of folic acid, vitamin B12 （VB12）, cholalic acid（CG）, interleukin（IL-2）, tumor necrosis factor（TNF）, hyaluronic acid （HA）, type Ⅳ collagen （Ⅳ-C）, transforming growth factor-α （TGFα）, and cortisol were detected by radioimmunoassay and analyzed. Results Compared with control, the serum contents of folic acid, Vit Bl2, IL-2, and TNF fell significantly （P 〈 0.01）, while the serum contents of CG, HA, Ⅳ.C, and TGFα rose significantly （P 〈 0.01 ）. There was no obvious difference （P 〉 0.05） in the serum contents of cortisol, between the arsenic group nd the control. While analyzed by delamination, there was marked difference between the serious group and the control （P 〈 0.01）. Conclusions RIA detecting of the above-mentioned nine materials in patients with coal type arsenic poisoning plays an important role in judging the range and degree of the body and in directing treatment.
出处
《中国地方病学杂志》
CAS
CSCD
北大核心
2004年第1期77-79,共3页
Chinese Jouranl of Endemiology
基金
全军"十五"面上基金A类资助项目(01MA048)
