摘要
背景:脑肠肽作为一类具有神经递质和激素双重功能的小分子多肽,在肠易激综合征(IBS)的发病机制中起重要作用。目的:研究血管活性肠肽(VIP),神经肽Y(NPY)和神经降压素(NT)水平在IBS患者血浆中的变化及其临床意义。方法:根据RomeⅡ标准纳入IBS患者36例,其中腹泻为主型IBS(D-IBS)24例,便秘为主型IBS(C-IBS)12例,同时纳入正常对照者10名。采用放射免疫测定分别检测受试者血浆VIP、NPY和NT水平。结果:D-IBS患者血浆VIP水平显著高于正常对照组(P<0.05),而C-IBS患者血浆VIP水平与正常对照组比较无显著差异(P>0.05);D-IBS和C-IBS患者血浆NPY水平均显著低于正常对照组(P<0.05和P<0.01),其中C-IBS患者又显著低于D-IBS患者(P<0.05);D-IBS和C-IBS患者血浆NT水平均显著高于正常对照组(P<0.05),但两亚型间比较无显著差异(P>0.05)。结论:IBS患者血浆脑肠肽水平与腹泻或便秘症状有一定的联系,表现为D-IBS和C-IBS患者的血浆NT水平均显著升高,而NPY和VIP水平因IBS亚型的不同而有差异。脑肠肽作为调节胃肠运动功能和感觉功能的重要因素,可能与IBS的发生、发展有必然的内在联系。
Background: Brain-gut peptides are a group of small molecular polypeptids, having dual function of neurotransmitters and hormones which play inlportant role in the pathogenesis of irritable bowel syndrome (IBS). Aims: To investigate the changes and clinical significance of brain-gut peptides such as vasoactive intestinal peptide (VIP), neuropeptide Y (NPY) and neurotensin (NT) in patients with IBS. Methods: Based on Rome II criteria, 36 IBS patients, including 24 diarrhea-predominant IBS (D-IBS), 12 constipation-predominant IBS (C-IBS), and 10 healthy subjects were enrolled in the study. The plasmal levels of VIP, NPY and NT were measured by radioimmunoassay (RIA). Results: The plasmal level of VIP was significantly higher in D-IBS patients than that in the normal controls (P〈0.05), but there was no significant difference between C-IBS patients and the normal controls (P〉0.05). The plasma NPY level in both D-IBS and C-IBS patients was significantly lower than that in the normal controls (P〈0.05, P〈0.01), and that in the C-IBS patients was significantly lower than that in the D-IBS patients. The plasma NT level in both D-IBS and C-IBS patients was significantly higher than that in the normal controls (P〈0.05), while there was no significant difference between the two subtypes (P〉0.05). Conclusions: Plasma brain-gut peptides levels in patients with IBS may be related to diarrhea and constipation. The plasma NT level is higher in both D-IBS and C-IBS patients than that in the normal controls, whereas there are differences of VIP and NPY in different subtypes of IBS. Brain-gut peptides act as important factors in regulating gastrointestinal motor and sensational function, which provide inevitable inner relationship of the genesis and development of IBS.
出处
《胃肠病学》
2005年第5期290-292,共3页
Chinese Journal of Gastroenterology