摘要
目的研究肝硬化病人的病毒感染状况及其与临床的关系。方法对398例住院肝硬化病人进行回顾性的研究,观察年龄、性别、病因、血清HBV标志物及HBVDNA、肝功能、ChildPugh评分。采用ELA、PCR、核酸杂交方法。结果男女比例为2.94:1;年龄无显著性差异;HBV感染居多(88.80%):HBsAg(+)90.99%、eAg(+)34.98%;HBsAg(-)的患者年龄明显高于样本组平均年龄。HBVDNA检测总阳性率为72.50%:eAb(+)者中HBVDNA(+)占91.22%;eAg(-)者中HBVDNA(+)占62.14%;eAg(-)同时eAb(+)者中HBVDNA(+)占26.13%。HBVDNA(+)组与HBVDNA(-)组比较,PTA明显下降及ChildPugh评分明显增加。HBV高度复制组年龄及AST项有增高的趋势,γ球蛋白增高显著。住院肝硬化病人以男性、HBsAg(+)、eAg(-)、HBVDNA(+)的慢性HBV感染者居多。结论HBV的活跃复制可加重肝损伤并导致肝衰竭。抗病毒治疗应该是慢性HBV感染过程中任何阶段的重要措施。
Objective To investigate the relationship between the infected state of HBV and the clinical manifestation of patients with liver cirrhosis. Methods Age,gender,etiopathogenesis, serum HBV marker, HBV DNA, hepatic function and Child-pugh score Were studied by retrospective analysis of 398 patients with liver cirrhosis. ELA, PCR and nucleic acid hybridization methods were used. Results The M-F ratio was 2.94： 1. The percentage of HBV infected cases was 88.80%, HBsAg （ ＋ ）90.99% and eAg （ ＋ ）34.98%. Mean age of patients with HBsAg （ - ） was older than that of sample group. The total positive percentage of HBV DNA was 72.50%, and that of HBV DNA（ ＋ ） in cAb（ ＋ ） group was 91.22% and in eAg （ - ） was 62.14%. The percent age of HBV DNA（ ＋ ）in patients with both eAg （ - ） and cab（ ＋ ） was 26.13%. Compared with the HBV DNA（ - ）group, HBV DNA（ ＋ ）group had the obviously lower level of PTA and higher Child-pugh score. The age and the level of AST in group of higher duplication had the ascending tendency and the step-up of γ-globulin was prominent. Conclusion The chronic HBV patients with HBsAg（ ＋ ） ,eAg（ - ） ,HBV DNA（ ＋ ） compose the main part of the patients with liver cirrhosis in hospital. The active duplication of HBV can aggravate the hepatic damage which could lead to hepatic failure. Antivural treatment should be the most important measure for HBV infected patients.
出处
《胃肠病学和肝病学杂志》
CAS
2005年第5期501-503,共3页
Chinese Journal of Gastroenterology and Hepatology
