摘要
目的研究细胞间黏附分子_1(1CAM_1)在原发性肝癌中的临床意义。方法以免疫组化方法结合全自动图像分析观察40例肝细胞癌组织及其癌旁组织和28例肝硬化组织中ICAM_1的表达。结果40例肝细胞癌组织ICAM_1表达阳性率为80.0%(32/40)、癌旁组织为57.5%(23/40)、肝硬化为53.6%(15/28),阳性率与组织学分类相关。肝癌组织中ICAM_1含量明显高于癌旁及肝硬化组织(P<0.05),转移组肝癌中ICAM_1的含量明显高于非转移组(P<0.05),而癌旁及肝硬化组织中表达差异无显著性(P>0.05)。结论肝癌组织中高度表达ICAM_1,ICAM_1有可能作为判断肝硬化及肝癌发展程度及预后的指标之一。
Objective To study the expression and significance of intercellular adhesion molecule-1（ICAM-1 ） in human hepatocellular carcinoma（HCC）. Methods Immumohistochemical staining was performed to detect the the expression of ICAM-1 in tissues of 40 cases of hepatocellular carcinoma, 40 cases of tumor surrounding liver and 28 cases of hepatic cirrhosis. Results The positive rate of ICAM-1 was 80.0%（32/40） for hepatocellular carcinoma,57.5% （23/40） for tumor surrounding liver and 53.6% （15/28） for hepatic cirrhosis respectively. The positive rates were significantly related to the histoligical types. Tissues ICAM-1 in hepatocellular carcinoma was higher in tumor surrounding liver and hepatic cirrhosis （ P 〈 0.05）, and was also higher in hepatocellular carcinoma with metastasis than those without metastasis （ P 〈 0.05）, and no significantly related in tumor surrounding liver and hepatic cirrhosis（ P 〉 0.05）. Conclusion Enhanced ICAM-1 expression was found in hepatocellular carcinoma tissues. ICAM-1 may be a marker of the growth and metastasis of hepatocellular carcinoma.
出处
《胃肠病学和肝病学杂志》
CAS
2005年第5期515-517,共3页
Chinese Journal of Gastroenterology and Hepatology
关键词
肝癌
肝硬化
细胞间黏附分子
Hepatocellular carcinoma
Hepatic cirrhosis
Intercellular adhesion molecule- 1
