期刊文献+

脑梗死和脑出血患者NO、ET和血液流变学变化的对照研究 被引量:4

The Comparison of NO,ET and Hemokinetics between the Cerebral Infarction and the Intracerebral Hemorrhage
下载PDF
导出
摘要 目的探讨脑梗死与脑出血患者NO、ET和血液流变学各项指标的改变,并探讨其临床意义。方法全组包括脑梗死66例、脑出血27例,健康对照组103例,分别以硝基还原酶法和放射免疫法测定血清NO含量和血浆ET含量,并检测患者血液流变学各项指标,脑梗死组及脑出血组分别与对照组比较,以及脑梗死组与脑出血组比较。结果与对照组相比,脑梗死与脑出血血流动力学与血液流变学各有多项指标出现显著变化。两组间比较,NO、ET的改变无显著性差异,低切全血粘度、高切全血粘度、血浆粘度、红细胞压积、红细胞聚集指数、刚性指数、电泳指数有显著性差异。结论脑梗死和脑出血患者血流动力学和血液流变学较正常对照组有显著差异,两组比较也有显著不同。 Objective To examine the diffcrence in plasma NO,ET levels and hemokinetics between patients of the cerebral infarction and the intracerebral hemorrhage. Methods Sixty-six cerebral infarction patients,27 intracerebral hemorrhage patients,and 103 healthy controls participated in this study. Plasma NO and ET were measured by nitratereductase and radioimmunoassay methods, respecdvely. And hemokinetics was determined in each subjects. The results were compared among the different groups. Results The results showed a significant difference between the patient group and the healthy control group. There was also a statistically signifiant difference between cerebral infarction and intracerebral hemorrhage patients on the blood viscosity at low and high shear rate, plasma viscosity, hematocrit, erythrocyte aggregation, rigidity, deformation and electrovhoresis. Conclusion This study suggested that there was a significant differences on NO, ET levels and hemokinetics between healthy controls and stroke patients,and as well as between patients with cerebral infarction and intracerebral hemorrhage.
出处 《中国血液流变学杂志》 CAS 2005年第2期233-235,共3页 Chinese Journal of Hemorheology
关键词 脑梗死 脑出血 NO ET 血液流变学 对照研究 cerebral infarction intracerebral hemorrhage NO ET hemorheology comparison
  • 相关文献

参考文献9

  • 1黄俊益,董仁寿.急性出血性脑血管病WBC、血液流变性变化的意义[J].中国血液流变学杂志,2002,12(1):30-31. 被引量:8
  • 2Laufs U,Endres M.Stagliano N,et al.Neuroprotection mediaed by changes in the endothelial actin cytoskeleton[J].J Clin Invest,2000,106:15~24.
  • 3Beridze M, Momtselidze N, Shakarishvili R, et al.Effect of nitric oxide initial blood levels on erythrocyte aggregability during 12 hours from ischemic stroke onset[J]. Clinical Hemorheology and Microcirculation,2004,30:403~406.
  • 4Cosentino F,Rubaattu S,Savoia C,et al.Endothelial dysfunction and stroke[J].J Cardiovasc Pharmacol,2001,38(Suppl 2):S75~S78.
  • 5Batteur-Parmentier S, Margaill I, Plotkine M.Modulation by nitric oxide of cerebral neutrophil accumulation after transient focal ischemia in rats[J].J Cereb Blood Flow Metab,2000,20:812~819.
  • 6Petrov T,Rails JA.Acute alterations of endothelin-1 and iNOS expression and control of the brain microcirculation after head trauma[J].Neurol Res,2001,23:139~143.
  • 7Suzuki Y,Fujita M, Mizutani N, et al.Role of nitric oxide in the control of cerebral microcirculation under physiological and pathological conditions[J].Clin Hemorheol Microcirc,2000,23:307~312.
  • 8张志琳,霍红梅,王运良,包仕尧.进展性脑卒中患者内皮素、一氧化氮含量的变化[J].河南实用神经疾病杂志,2004,7(4):8-9. 被引量:21
  • 9王伟,杨渊,潘邓记,胡晓晴,张英秀,张苏明.急性脑出血患者的缺血危险因素分析[J].卒中与神经疾病,2001,8(2):88-90. 被引量:10

二级参考文献16

共引文献35

同被引文献38

引证文献4

二级引证文献24

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部