摘要
目的调查成年女性体表面积(BS)与不同骨骼部位骨密度(BMD)之间的关系,及BS大小不同的受试者各骨骼部位患骨质疏松的风险。方法用双能X线骨密度仪测量3418例成年女性腰椎后前位、侧位及髋部和前臂BMD。结果BS与不同骨骼部位的BMD呈显著性正相关(r=0.114～0.373,P=0.000),但与腰椎侧位体积BMD(vBMD)不相关。以身高、体重、体重指数(BMI)、体表面积(BS)作为自变量,以BMD作为因变量的多元逐步回归分析显示:影响后前位腰椎、髋部和前臂BMD的最重要的变量是BS。按BS大小将该人群分为3组:大体表面积组(LBSG)、中等体表面积组(IBSG)和小体表面积组(SBSG)。各骨骼部位的BMD按BS大小呈递增变化(腰椎侧位除外):LBSG>IBSG>SBSG;而骨质疏松的患病率和发病风险向相反的方向变化:LBSG<IBSG<SBSG。结论成年女性BS与BMD的关系超过身高和体重。用面积BMD表达时,BS较大者BMD较高和患骨质疏松的风险较小,BS较小者BMD较低和患骨质疏松的风险较大。用vBMD表达时,这些差异缩小甚至消失。
Objective To investigate the relationship between body surface area （BS） and bone mineral density （BMD） and the associated osteoporosis risk at various skeletal regions in adult women. Methods BMD was measured at the posteroanterior （PA） spine （ L1-L4 ）, supine lateral spine （ L2-L4 ） including volumetric BMD （vBMD）, hip including femoral neck, trochanter and total hip, and forearm including radius ＋ ulna ultradistal （R ＋ UUD）, 1/3 site （R ＋ U1/3） and total region （R ＋ UT） using dual-energy X-ray absorptiometry （DXA） bone densitometerin 3418 females aged from 18 to 75. Three groups were divided according to BS： large （LBSG）, intermediate （IBSG） and small BS group （SBSG）. Results A positive correlation was shown between BS and BMD at various skeletal regions （ r = 0.114 - 0.373, P = 0.000）, but not with vBMD （ r = 0.000, P = 0.934）. Multiple stepwise regression model analysis revealed that BMDs at various skeletal regions were dependent variables while height, weight, body mass index （BMI）, BS and projective bone area（BA） were independent variables ; BS was determined to be the most important variable affeetting the PA spine, hip and forearm BMDs. The BMD at different skeletal regions of subjects between groups exhibited a significant gradient difference, with LBSG 〉 IBSG 〉 SBSG, but not for vBMD. On the other hand, the prevalence rates and risks of osteoporosis presented a conversely significant gradient difference,with LBSG 〈 IBSG 〈 SBSG. Conclusions BS is much more related to BMD than height or weight in adult women. When area BMD is applied, the larger the BS,the higher the BMD and the risk of osteoporosis. But when vBMD is used, these differences diminish or even disappear.
出处
《中国骨质疏松杂志》
CAS
CSCD
2005年第3期306-310,305,共6页
Chinese Journal of Osteoporosis
