摘要
目的:观察对药物过敏史眼科患者,行眼底荧光血管造影时静脉注射荧光素钠的不良反应情况。方法:对有药物过敏史250例和同期无药物过敏史250例眼病患者,静脉注射荧光素钠进行眼底荧光血管造影(fundusfluoreceinangiography,FFA),观察有无不良反应及药物反应情况。结果:有药物过敏史250例中25例发生不良反应,其中荧光造影检查中发生药物反应20例,检查后发生过敏反应5例;无药物过敏史250例中有23例发生不良反应,其中荧光造影检查中发生药物反应18例,检查后发生过敏反应5例。两组均无1例发生心脏骤停等危及生命的严重反应。两组过敏反应发生情况无统计学差异(χ2=0.165,P<0.01)。结论:药物过敏史眼科患者并非FFA绝对禁忌症,但应当强调严格观察注射稀释荧光素钠进行的过敏试验,检查室内常规准备各种急救药品和条件,以便预防万一出现的严重过敏反应。
AIM： To observe the clinical adverse effect of fundus fluorecein angiography on 250 pateins with drug hypersensitivity. METHODS： Two hundred patients with drug hypersensitivity history and 250 patients with no-drug sensitive history were examined by fundus fluorescein angiography （FFA） by intravenous injection of fluorescein sodium. The clinical adverse effect of the drug were observed retrospectively. RESULTS： Twnety-five cases of the patients with drug hypersensitivity history had adverse reaction, among them 20 patients were allergic to the drug during the FFA examination and 5 patients after FFA. Twenty-three cases of the patients without drug allergic history had adverse reaction, including 18 patients during the FFA examination and 5 patients afterwards. There was no statistical difference of the allergic reaction in the two groups （x^2= 0.165, P〈0.01）. CONCLUSION： Drug hypersensitivity history is not the absolute contraindication for FFA. But all patients should take sensitive test of fluorescein sodium before FFA. It is important to prepare various kinds of first aid drug and routine equipments in examination room to prevent serious allergic reaction.
出处
《国际眼科杂志》
CAS
2005年第5期1061-1063,共3页
International Eye Science
