摘要
目的观察不稳定型心绞痛(UAP)患者血清肌钙蛋白I(cTnI)含量的变化及其与患者预后的关系,并探讨cTnI与冠状动脉病变程度的关系。方法测定91例UAP患者血清cTnI、磷酸肌酸激酶同工酶(CK-MB)的含量。分析其一般临床特征、冠状动脉病变情况,观察心脏事件发生率,用Logistic回归分析相关因素的影响。结果91例UAP患者中cTnI增高者43例,cTnI增高组与cTnI正常组冠状动脉病变支数、冠状动脉狭窄程度积分比较差异无显著性(P>0.05),通过对心脏事件相关因素的分析,cTnI增高是发生心脏事件的独立危险因素,其相对危险度的估计值为15.82(P<0.01)。结论血清cTnI是UAP患者危险度分层及判断预后的重要生化指标。
Objective To observe the relationship between the serum cTnI content and the prognosis in patients with unstable angina pectoris （UAP）, and to investigate the relationship between serum cTnI content and the severity of coronary artery, lesions. Methods The serum cTnI and CK-MB level of 91 UAP patients were determined. The clinical feature, severity of coronary artery lesion and occurrence of cardiac event were analyed, with logistic regression. Results In the 91 UAP patients, 43 patients had an elevated serum cTnI level. There was no difference in the number of lesioned artery and score of coronary artery stenosis between the normal and high cTnI group. According to the correlation factors analyze, cTnl level was an independent risk factor to cardiac event, the relative risk value was 15.82（P 〈 0.01）. Conclusion Serum cTnI level is an important biochemical indicator on the risk grading and prognosis estimation of UAP patients.
出处
《中国心血管杂志》
2005年第5期340-342,349,共4页
Chinese Journal of Cardiovascular Medicine
关键词
冠心病
不稳定型心绞痛
肌钙蛋白Ⅰ
预后
Coronary heart disease
Unstable angina pectoris
Cardiac troponin Ⅰ
Prognosis
