摘要
犬静脉注射ＡＦ－ＤＸ１１６０．０５，０．５，５ｍｇ／ｋｇ均导致①呼吸频率、潮气量、每分通气量明显增加（Ｐ＜０．０５或０．０１），均呈剂量依赖关系。②ＰａＯ２升高，ＰａＣＯ２降低。０．２０ｍｇ／ｋｇ椎动脉注射亦产生与静脉给药相似的呼吸兴奋效应。ＡＦ－ＤＸ１１６还能拮抗６β－ＡＮ的呼吸抑制作用，表明，ＡＦ－ＤＸ１１６有呼吸兴奋作用，并可能与其阻滞呼吸中枢Ｍ２受体有关。
The excitatory effect of AF-DX 116 on respiration and its relation to M2-receptors Were studied in dogs.It was found that the respiratory frequency(FR),ventilation volum.(Vm)and PaO2 were increased and the PaCO2 was decreased following administration of AF-DX 116 0.05～5mg/kg iv. The excitatory effects on FR and Vm were dose-dependent in manner.when small doses of AF-DX 116 were given by ia route,an excitatory effect was observed similar to the result following the drug given by iv route. AF-DX 116 given either by iv or ia route, antagonized the inhibitory effect of 6β-AN, which stimulates M2 receptors,It appears that the excitatory action of AF-DX 116 on respiration might be related to the block of inhibitory M2 cholinergic receptors in the respiratory center.
出处
《徐州医学院学报》
CAS
1996年第2期126-128,共3页
Acta Academiae Medicinae Xuzhou
