摘要
为观察维胺酸对地鼠颊囊癌前病变的阻断作用及对临床口腔白斑的治疗效果，作者采用０．５％二甲基苯蒽涂抹金黄地鼠颊囊制成癌前病变模型，再给予维胺酸治疗。８２只实验动物分为口服、局部治疗、口服加局部治疗及对照４个组。分别于用药８周和停药８周观察并取活检，光学显微镜下观察动物颊囊粘膜上皮的改变。结果发现，该药对癌前病变有明显的阻断作用。将维胺酸用于临床治疗口腔白斑有明显的治疗效果，有效率达８４．０％，与对照组相比差异有显著性；部分病例可逆转为正常组织。实验证明用该药治疗癌前病变，有其理论意义和实用价值。
Inhibitionofbuccalpouchcarcinogenesisinducedbydimethyl-benzanthraceneinham-sterswithretinamidewasstudied.GroupAreceivedoralretinamideatadosageof20mg/kg,everydayforeightweeks.GroupBwastreatedbyretinamideoralyatthesamedosage,plustopicaltreat-mentbyretinamide.GroupCwastreatedbyretinamidetopicalyforeightweeks.Experimentsex-hibitedthatundertheactionofretinamidetheincidenceoftumorwasloweredsignificantly.AltheGroupA,BandChadagoodresponse.Clinicaly80patientswererandomlyarangedintotwogroups.Onegroupreceivedplaceboandservedascontrolsandtheothergroupwastreatedbyreti-namide.Resultsindicatethatretinamideisefectiveagainstleukoplakiaandtheresponserateisashighas84.0%.Bycontrast,only16.7%ofpatientsreceivingplaceboshowedsomeimprovement.
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
1996年第3期185-187,共3页
Chinese Journal of Stomatology
