摘要
24例由组织学或/和细胞学诊断的恶性胸腔积液,经胸腔内灌注相当4倍机体最大耐受剂量(MTD)的肿瘤坏死因子(TNF4×106单位)进行治疗,CR18例,PR4例,NC2例,有效缓解率91.7%(22/24)。毒副反应:高热16例(66.7%),疼痛14例(58.3%),经对症处理可缓解。与其他胸水治疗方法比较,该方法具有疗效高,毒副反应低的特点。
Twenty four cases with malignant pleural effusion confirmed either histologically or by cytology were treated by tumor necrosis factor(TNF)instillation 4 times the dosage of routine maximum tolerance dosage.CR was achieved in 18 cases,PR in 4 cases,NC in 2 cases. The overall response rate was 91.7%(22/24).Side reactions consisted of high fever in 16 cases(66. 7%),Chest pain in 14 cases (58.3%)which were relieved by appropriate measures.This approach of therapy was superior to other modalities of managements in terms of high efficacy and lower toxicity.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1996年第4期263-265,共3页
Chinese Journal of Clinical Oncology
关键词
恶性胸腔积液
药物疗法
肿瘤坏死因子
Malignant pleural effusion High dosage of tumor Tumor necrosis factor instillation lung cancer Intrapleural instillation