摘要
目的 观察胸膜腔内灌注丝裂霉素治疗恶性胸膜腔积液的疗效。方法 对15例恶性胸膜腔积液病人采用胸膜腔闭式引流术，1-2d排空胸膜腔积液，后注入100mL生理盐水＋20mg丝裂霉素，夹闭引流管4h后开放，间隔1d再同样方法用1次，引流无液体后拔出引流管，4wk后评价疗效。结果 病人呼吸困难明显好转，生活质量明显改善。CR10例，PR3例，NC2例，总有效率86．7％（13／15）。结论 胸膜腔内灌注丝裂霉素能有效控制恶性胸膜腔积液，对晚期肿瘤所致恶性胸水的病人有重要意义。
Objective To observe the efficacy of treating malignant pleural effusion by mitomycin thoracic cavity perfusion. Methods 15 patients with malignant pleural effusion were performed thoracic cavity drainage, evacuation after 1 to 2 days, drainage after 4 hours perfusion with 10ml NS, and 20mg mitomycin. The same procedure was repeated in one day, drainage-tube was removed after no more drainage, and then the efficacy was evaluated after 4 weeks. Results The symptom and quality of life were significantly improved （CR 10 cases, PR 3 cases and NC 2 cases, the efficiency is 87%）. Conclusion mitomycin thoracic cavity perfusion could effectively control malignant pleural effusion, and has significance to patients with advanced stage cancer.
出处
《世界肿瘤杂志》
2005年第3期208-209,共2页
Tumour Journal of the World
