摘要
目的探讨早期区域动脉灌流(LAI)对重症急性胰腺炎(SAP)预后的影响。方法对2000年1月至2004年8月本院普外ICU收治的74例SAP患者进行回顾性研究。LAI组30例,常规治疗组44例,比较两组SAP并发症发生率和病死率。结果LAI组患者SAP并发症发生率、手术率和病死率比常规治疗组低,但差异无显著性(P>0.05)。结论LAI在降低SAP并发症发生率和病死率方面有较好疗效,这是治疗SAP的重要辅助手段。
Objective To study the effects of early local arterial infusion （LAI） on the prognosis of severe acute pancreatitis （SAP）. Methods Seventy-four SAP patients, admitted from January 2000 to August 2004, were retrospectively analyzed. The 74 patients, 43 male and 31 female, aged （62.54 ± 14.79） years old, were divided into two groups according to the treatments： LAI group （ n = 30） and control group （ n = 44）. Complications and mortality between the two groups were compared. Seldinger＇s method was used. Catheter was placed in the artery that irrigated the inflammatory area of the pancreas with continuously infusion with protease inhibitor and antibiotics within 24 hours after ICU admission in the LAI group. Results The base-line characteristics of the two groups were similar （ P 〉 0.05 ）. APACHE Ⅱ score at 3 days after adlmission in LAI group was significantly lower than that in control group （ P = 0.051 ）. Moreover, APACHE Ⅱ score at 1, 2, 3 days after admission was significantly lower than that on admission day in LAI group （ P 〈 0.05） ; however, the differences in APACHE Ⅱ scores were not significant on admission day, and 1, 2, 3 days after admission in the control group （ P 〉 0.05 ）. Although complications, such as gastrointestinal hemorrhage, paralysis of intestine, pancreatic abscess, sepsis and multi-organ failure, were reduced in the LAI group, and mortality of pancreatitis in LAI group was lower than that in control group, there didn＇t exist significance （ P 〉 0.05 ） . Conclusion LAI can reduce SAP complications and mortality, which is benefial in treating SAP.
出处
《中华急诊医学杂志》
CAS
CSCD
2005年第11期925-927,共3页
Chinese Journal of Emergency Medicine
