摘要
基质金属蛋白酶的含量和活性在脑缺血、颈动脉粥样硬化斑块、脑动静脉畸形、脑动脉瘤等病理状态下明显增高,提示该蛋白酶与脑血管疾病的发生关系密切。动物试验显示,基质金属蛋白酶抑制剂能明显减小脑梗死体积及脑损伤范围,并可稳定易破裂的动脉粥样硬化斑块,抑制脑动脉瘤的膨胀。由此基质金属蛋白酶可能成为防治脑卒中的新靶点。
出处
《国际神经病学神经外科学杂志》
2005年第5期447-451,共5页
Journal of International Neurology and Neurosurgery
参考文献25
-
1Montaner J, Alvarez-Sabin J, Molina C, et al. Matrix metalloproteinase expression after human cardioembolic stroke: temporal profile and relation to neurological impairment. Stroke, 2001 , 32(8) : 1759-1766.
-
2Sehba FA, Mostafa G, Knopman J, et al. Acute alterations in microvascular basal lamina "after subarachnoid hemorrhage. J Neurosurg, 2004, 101(4): 633-640.
-
3Gaetani P, Rodriguez Y, Baena R, et al. Metalloproteases and intracranial vascular lesions. Neurol Res, 1999, 21 ( 4 ) : 385-390.
-
4Newby AC. Dual Role of Matrix Metalloproteinases (Matrixins) in Intimal Thickening and Atherosclerotic Plaque Rupture. Physiol Rev, 2005, 85(1): 1-31.
-
5Hashimoto T, Wen G, Lawton MT, et al. Abnormal expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in brain arteriovenous malformations. Stroke, 2003, 34 (4):925 -931.
-
6Lee CZ, Xu B, Hashimoto T, et al. Doxycycline suppresses cerebral matrix metalloproteinase-9 and angiogenesis induced by focal hyperstimulation of vascular endothelial growth factor in a mouse model. Stroke, 2004, 35(7): 1715-1719.
-
7Pfefferkorn T, Rosenberg GA. Closure of the blood-brain barrier by matrix metalloproteinase inhibition reduces rtPA-mediated mortality in cerebral ischemia with delayed reperfusion. Stroke,2003, 34(8) : 2025-2030.
-
8Asahi M, Wang X, Mori T, et al. Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia. J Neurosci,2001, 21(19) : 7724-7732.
-
9Romanic AM, White RF, Arleth A J, et al. Matrix metalloproteinase expression increases after cerebral focal ischemia in rats: inhibition of matrix metalloproteinase-9 reduces infarct size. Stroke,1998, 29(5) : 1020-1030.
-
10Alvarez-Sabin J, Delgado P, Abilleira S, et al. Temporal profile of matrix metalloproteinases and their inhibitors after spontaneous intracerebral hemorrhage: relationship to clinical and radiological outcome. Stroke, 2004, 35(6): 1316-1322.
同被引文献34
-
1刘昱言,刘轲,刘敬霞,李建生.基质金属蛋白酶-2、-9与脑缺血微血管损伤的关系[J].中国老年学杂志,2014,34(1):257-259. 被引量：5
-
2边玉松,罗祺.基质金属蛋白酶与颅内动脉瘤[J].国外医学（脑血管疾病分册）,2005,13(1):59-62. 被引量：1
-
3郝玉曼,罗祖明,高励,张仲,曾伟.局灶性缺血预处理对鼠脑核因子-κB基质金属蛋白酶-9基因表达及脑水肿的影响[J].中华老年医学杂志,2005,24(3):217-220. 被引量：4
-
4孙晓枫,乔桂荣,兰海涛,张庆俊.肾性高血压大鼠脑动脉瘤形成过程中NF-kB和MMPs表达的关系[J].中华神经外科杂志,2006,22(10):628-632. 被引量：14
-
5Hashimoto T,Wen G,Michael T,et al.Abnormal expression of matrix metalloproteinases and tissue inhibitors of metallopmteinases in brain arteriovenous malformations.Stroke,2003,34:925-931.
-
6Lee SR,Tsuji g,Lee SR,et al.Role of matrix metalloproteinases in delayed neuronal damage after transient global cerebral ischemia.J Neurosci,2004,24:671-678.
-
7Antonetti DA,Barber A J,Hollinger LA,et al.Vascular endothelial growth factor induces rapid phosphorylation of tight junction proteins occluding and zonula occluden-1.Biol Chem,1999,274:23463-23467.
-
8Donzelli R,Maiuri F,Piscopo GA,et al.Role of ext racellular matrix components in facial nerve regeneration:an experimental study.Neurol Res,2006,28:794-801.
-
9Lee CZ,Xue Z,Zhu Y,et al.Matrix metalloproteinase-9 inhibition attenuates vascular endothelial growth factor-indaced intracerebral hemorrhage.Stroke,2007,38:2563-2568.
-
10Heo JH,Kim SH,Lee KY,et al.Increase in plasma matrix metalloproteinase-9 in acute stroke patients with thrombolysis failure.Stroke,2003,34:48-50.
引证文献4
-
1徐宏治,陈衔城,孙安,秦智勇,顾宇翔.基质金属蛋白酶2、9基因表达变化与脑动静脉畸形出血的关系[J].中华神经外科杂志,2010,26(1):37-39.
-
2金点石,熊文德,丛培雨,李旭琴,陈晓旭,于军.MMP、TIMP在颅内动脉瘤中表达的实验研究[J].中华神经外科杂志,2013,29(3):230-233. 被引量：5
-
3黄奕平,俞敏,张丽君.基质金属蛋白酶-1、基质金属蛋白酶-3、基质金属蛋白酶-9主要基因位点多态性与缺血性脑血管病的相关性分析[J].吉林医学,2022,43(8):2034-2037. 被引量：2
-
4沈焱,李伟,刘志梅,张启帆,许瑞庭.基质金属蛋白酶-9基因的多态性与缺血性脑血管病颈动脉粥样硬化不稳定斑块相关性研究[J].宁夏医学杂志,2023,45(7):585-588.
二级引证文献7
-
1李明超,郭永涛,李正明,高杜荣,孙洪刚.颅内动脉瘤破裂经介入栓塞治疗前后血清MMP-2、MMP-9的变化与预后研究[J].现代医学,2018,46(2):144-149. 被引量：9
-
2余舟,廖可立,黄颂,赵清.显微外科手术治疗对颅内动脉瘤患者预后及血浆MMP和TIMP表达的影响[J].中国肿瘤临床与康复,2018,25(4):419-422. 被引量：2
-
3冯涛,王宗社,舒端朝,张顺军.主动脉瘤患者围术期基质金属蛋白酶、基质金属蛋白酶抑制因子、白细胞介素检测及临床意义[J].陕西医学杂志,2019,48(8):1094-1097. 被引量：5
-
4魏海亮,李建华,李翠君.双微导管联合弹簧圈栓塞治疗对颅内动脉瘤患者预后情况及血浆MMP、TIMP表达的影响[J].中国现代药物应用,2019,13(22):1-5. 被引量：2
-
5王介南,朱悦琦.炎症在颅内动脉瘤破裂中作用的研究进展[J].介入放射学杂志,2021,30(4):423-428. 被引量：7
-
6叶兰香,陈俊斌,李雪莲.眼底血管病变与急性缺血性脑卒中溶栓后出血转化的相关性[J].吉林医学,2024,45(3):541-544.
-
7赵晓慧,李德辉,高维娟.基于数据挖掘技术探讨醒脑开窍针刺治疗缺血性脑血管病的作用机制[J].针灸临床杂志,2024,40(7):73-79.
-
1涂悦,马铁柱,吴绘.基质金属蛋白酶与脑缺血研究进展[J].医学综述,2006,12(1):55-57. 被引量：4
-
2杨晨辉,范洪光,刘莹,张祥建.基质金属蛋白酶与出血性转化[J].国际脑血管病杂志,2008,16(4):285-288. 被引量：1
-
3李杰,李光勤.基质金属蛋白酶与溶栓后出血性转化[J].国外医学（内科学分册）,2006,33(4):173-176. 被引量：3
-
4闫长祥.突发头痛是怎么回事[J].家庭医药（就医选药）,2016,0(11):61-61.
-
5陈玉珊.左氧氟沙星的不良反应分析[J].河北医药,2012,34(16):2523-2524. 被引量：7
-
6陈泰卫,周德华,孟尽海.异氟醚控制性降压用于脑血管手术[J].海南医学院学报,1999,5(3):119-121.
-
7丁娜.血清超敏C反应蛋白 同型半胱氨酸水平与卒中后抑郁的关系[J].中国实用神经疾病杂志,2014,17(8):99-100. 被引量：12
-
8李传素.精神分裂症合并糖尿病患者的临床护理[J].重庆医学,2008,37(4):444-444.
-
9夏树剑.基底动脉尖综合征危险因素分析[J].浙江实用医学,2011,16(1):1-3. 被引量：1
-
10徐飙,徐忠.口服避孕药与患病危险性的综合研究[J].中华妇产科杂志,1996,31(12):724-727. 被引量：2
