摘要
目的观察生理性起搏联合索他洛尔对病窦综合征(SSS)患者房性快速心律失常的预防作用。方法52例伴严重房性快速心律失常的SSS患者,在植入DDD起搏器1个月后,分为70次/分单纯起搏(A组)、60次/分起搏+索他洛尔80 mg/d(B组)和70次/分起搏+索他洛尔80mg/d(C组)三组,随访治疗8周时自动模式转换(AMS)、高频心房事件(HARE)和连发房早(PACR)的发生次数。结果三组患者的房性快速心律失常均显著下降,AMS、HARE分别下降42%、56%、87%和45%、56%、87%,起搏+药物治疗组(B组或C组)与单纯起搏组(A组)比较差异均有显著性(P<0.05),以C组更明显。结论生理性起搏联合索他洛尔对预防SSS患者的房性快速心律失常有显著作用。
Objective To evaluate combination therapy of physiological pacing and sotalol in the prevention of atrial taehyarrhythmias in patients with sick sinus syndrome. Methods A total of 52 SSS cases with atrial tachyarrhythmias after DDD pacemaker implanted one month before were divided into three groups,single pacing with 70ppm（ group A） ,60ppm pacing with sotalol 80mg/d（ group B）and 70ppm pacing with sotalol 80mg/d （group C ）. Automatic mode switching （AMS）, higher atrial rate epsiodes （HARE） and premature atrial complexes runs（PACR） were analysed after eight weeks of treatment. Results The occurrence rate of atrial taehyarrhythmias was decreased obviously in all three groups. The AMS and HARE were decreased by 42% ,56 % ,87% and 45% ,56% ,87% ,respectively. The diffienee in combination therapy （ group B or group C ） and single pacing therapy （ group A） was significant different and more obviously in group C. Conclusions Physiological pacing with combination of sotalol therapy was effective in the prevention of atrial taehyarrhythmias in patients with SSS.
出处
《临床内科杂志》
CAS
2005年第11期747-748,共2页
Journal of Clinical Internal Medicine
关键词
心脏起搏
索他洛尔
心房颤动
病窦综合征
Cardiac pacing
Sotalol
Atrial fibrillation
Sick sinus syndrome
