摘要
为探讨自由基对瘢痕疙瘩中胶原沉积的影响,应用电子自旋共振(ESR)技术检测了人体瘢痕疙瘩、正常皮肤组织及结缔组织。结果发现瘢痕疙瘩和结缔组织样品中有氧自由基存在,而正常皮肤组织内则未能检测到。文中就氧自由基的产生与瘢痕疙瘩中胶原合成异常的关系进行了探讨,氧自由基清除剂的应用可能有助于防治瘢痕的过度增生。
Electron spin resonance(ESR)was used to examine human keloid,normal connective tis- sue and skin.The results showed that more oxygen free radicals were identified in keloid,less in normal connective tissue while no free radicals were found in skin.The author discussed the significance of the occurrence of oxygen free radicals and its relation with keloid and suggested that reduction or elimina- tion of production of oxygen free radicals by its scavenger may be of help in preventing the excessive growth of scar tissue.
关键词
电子自旋共振
氧自由基
瘢痕疙瘩
胶原
Electron spin resonance(ESR)
Oxygen free radicals
Keloid
