摘要
目的探讨肝动脉化学栓塞(TACE)联合三维适形放射治疗(3DCRT)对中晚期原发性肝癌的疗效。材料和方法对19例中晚期原发性肝癌进行了肝动脉化学栓塞联合三维适形放射治疗,TACE灌注化疗药物丝裂霉素C20mg,5-氟尿嘧啶1000￣1500mg,顺铂60￣80mg,栓塞剂为40%碘化油,治疗1￣3次;三维适形放疗应用Topslane计划系统,6MV-X直线加速器实施治疗,4￣8个适形固定野,计划靶体积13.3￣907cm3,总剂量30￣48Gy,每次4￣7Gy,连续照射6￣10次。结果近期有效率(CR+PR)74%,1、2年生存率分别为79%和42%,治疗前后毒副反应无明显差异。结论肝动脉化学栓塞联合三维适形放疗能提高中晚期原发性肝癌的治疗效果,但不增加毒副作用。
Objective To evaluate the effects of combined transcatheter arterial chemoembolization （TACE） and three-dimensional conformal radiation therapy （3DCRT） for advanced hepatocellular carcinoma. Methods 19 patients were treated by TACE and 3DCRT. For TACE, 20mg Mitomycin C, 1 000 - 1 500 mg 5-fluorouracil and 60 - 80 mg Cisplatin were perfused into the hepatic arteries, and 10 - 20 ml of iodized oil were given to embolize the hepatic arteries, each patient was treated with 1 - 3 sessions. For 3DCRT, the planning was designed by Topslane system, radiation was given by 6 -MV X-ray, 4 - 7 Gy per session every day, 6 - 10 times, a total dose of 30 - 4.8 Gy were given to planned target volume （PTV） 13.3 - 907 cm^3. Results The response rate （CR ＋ PR） was 74%, The 1 and 2 year＇s survival rates were 79% and 42%. Conclusion For unresectable hepatocellular carcinoma, TACE and 3DCRT can significantly prolongs the patients survival.
出处
《现代消化及介入诊疗》
2005年第3期140-142,共3页
Modern Interventional Diagnosis and Treatment in Gastroenterology
