摘要
目的:评价奥沙利铂(OXA)联合亚叶酸钙(LV)和5-氟尿嘧啶(5-Fu)一线治疗晚期胃肠道肿瘤疗效与安全性.方法:OXA130mg/m2,第1天;LV200mg,第1～5天;5-Fu450mg/m2,第1～5天.每3周为1周期,至少2周期后评价疗效.结果:58例,均为术后转移或不能手术切除患者,其中CR 2例(3.4%),PR 26例(44.8%),SD 21例(36.2%),PD 9例(15.5%),总有效率(CR+PR)48.3%.有手术史者有效率54.5%,不能手术者有效率40.0%;胃癌有效率44.4%,大肠癌有效率51.6%.主要不良反应为恶心呕吐、轻度周围神经毒性及白细胞和血小板减少,无化疗相关死亡.结论:OXA联合LV和5-Fu一线治疗晚期胃肠道肿瘤有较好的疗效和耐受性.
Objective： TO evaluate the efficacy end safety of Oxallplatin（OXA）/LV/5-Fu regimen as first-line treatment for patients with metastatic gastrointestinal cancers. Methods： OXA 130mg/m^2 d1, LV 200mg d1-5 followed Dy 5-Fu 450mg/m^2 d1-5, ond repeated every 3 weeks. Efficacy was evaluated after 2 cycles（6 weeks）. Results： Fifty-eight patients were entered into the study. All patients were metastatic after a curative resection or metastatic without a curative resection.. All patients were evaluated for clinical response and toxicity. 2 patients achieved OR（3.4%）,26 PR（44.8%）, 21 SD（36.2%）, and 9 PD（15.5%） ,ORR 48.3%. Overall response rate for patients with gastric cancer or colorectai cancer, and patients reseated or non-resected were 44.4%, 51. 6%, 54.5%, 40.0% respectively. The most frequent side. effects were nausea/vomiting, neurotoxlclty, leucopenia and thrombocytopenia,and there were no deaths during treatment.Conclusion ： OXA/LV/5-Fu is a high resDonse regimen for metastatic gastrointestinal cancers with mild toxicity, which can be practiced safely.
出处
《中国现代普通外科进展》
CAS
2005年第2期115-117,共3页
Chinese Journal of Current Advances in General Surgery
