摘要
目的:研究长期口服茶碱缓释片治疗慢性阻塞性肺疾病(COPD)时,用St.George’s呼吸疾病询问表(SGRQ)和国内的生存质量表作为终点指标测评疗效的可行性,并研究量表与肺功能之间的相关性。方法:采用病例对照研究。结果押治疗组肺功能指标FVC、FEV1显著高于对照组,有显著差异(P<0.05和P<0.01)(治疗组治后64.57±16.92,57.25±13.51,对照组治后:53.69±16.34,32.44±16.27)。QOL结果:治后国内量表表明:总均分、日常生活能力、社会活动、抑郁症状、和焦虑症状在治疗组中治疗后显著降低,有显著差异。(治前1.80±0.23,1.67±0.37,2.11±0.5,1.72±0.36,1.80±0.39,治后1.41±0.21,1.31±0.3,1.50±0.3,1.45±0.29,1.48±0.39)(P<0.01);SG R Q量表中总评分、活动能力、社交心理影响治疗后较对照组显著降低(P<0.01),有显著差异,(治疗组治后43.85±11.07,43.85±11.07,40.17±11.08;治后53.69±13.40,72.35±10.23,48.33±11.37)。直线回归分析表明SG R Q的症状与FEV 1有直数相关(P=0.002)。而国内生存质量量表与FEV 1/FVC有直数相关(P=0.001),二者均表明随着肺功能的下降生存质量也随之降低。结论:长期口服缓释茶碱可改善病人生存质量,SG R Q和国内生存质量量表均能较敏感地观察治疗前后的改变,与肺功能有较密切的相关性,国内开发的量表也可作为综合疗效的测量工具。
Objective： to understand the effects in COPD treated with theophylline that are evaluated by SGRQ and questionnaire in internal as outcome measures, and to study the relationship between them. Methods： random case-control study. Patients were classified as two groups （treatment group and matched group） that taking successive or not theophylline sustained-release tablets. In the treatment group of 30 cases, theophylline sustained-release tablets administrated successive in 100mg Bid. In the matched group 40 cases didn＇t administrate. Results： the two groups were weU balanced for a demographics and baseline data. There were no significant differences （P〉0.05）. In the treatment group of 30 cases, 28 cases had fulfilled the course of treatment the mean age was 64.5±7.0 （male 13, female 15）; in the matched group of 40 cases, 37 cases fulfilled, the mean age was 65.5±7.8 （male 21, female 16）. After one year, lung function were higher than control group that were lower than before treatment, FVC （P〈0.05）,FEV1 （P〈0.01）（after 64.57±16.92, 57.25±13.51, matched group： after： 53.69±16.34, 32.44±16.27）. There was a significant difference. QOL： TMS, daily life ability, social activities, depression anxiety state were lower in the treatment group （before：1.80,±0.23, 1.67±0.37, 2.11±0.5, 1.72±0.36, 1.80±0.39, after：1.41±0.21, 1.31±0.3, 1.50±0.3,1.45±0.29, 1.48±0.39）（P〈0.01）. SGRQ： TMS, activity, and impacts were lower than treatment before in the treatment group, there was a significant difference（P〈0.01）. （Treatment group： after treatment 43.85±11.07, 43.85±11.07, 40.17±11.08 ;Matched group： after treatment 53.69± 13.40, 72.35±10.23, 48.33±11.37）. Relationships between the lung and function GOL scores： Linear correlation analysis showed that Symptoms scores in SGRQ had a linear relative to FEV1 （P=0.002）. Conclusion： theophylline sustained-release tablets administrated may improve GOL in COPD, it is relative to increase the lung function. We think that SGRQ and questionnaire in internal could measure treatment effect sensitively. This show that questionnaire in internal is a good instrument to evaluate treatment effect.
出处
《金华职业技术学院学报》
2005年第4期104-109,共6页
Journal of Jinhua Polytechnic
基金
金华市科技局科研项目(项目编号:2004-1-360)
