摘要
目的:选择合适的大鼠炎性肠病(IBD)模型,观察中药灌肠Ⅰ号对其治疗作用,为IBD治疗寻找新途径。方法:Wistar大鼠80只,分为正常对照组、模型组、西药sulfasalazine(SASP)组和中药灌肠Ⅰ号组,每组动物20只。分别在用药后4,7,14,21 d观察外周血细胞变化与肠道病理学指标。结果:给药7 d后SASP组和中药组外周血小板数都比模型对照组明显升高。组织病理学观察显示SASP组对于IBD的远期治疗作用不甚明显,而灌肠Ⅰ号确实有减轻IBD病变,促进其修复的作用,近期与SASP相当,远期优于SASP。结论:中药灌肠Ⅰ号有较明显的抗大鼠炎性肠病效果。
Objective： To observe the effect of the clysters No. 1 of Traditional Chinese Medicine（TCM） in inflammatory bowel disease on rats and search the new way and evidence for IBD cures. Method： The rats were divided into four groups： normal control group（Ⅰ）, model control group（Ⅱ）, Stdfasalazine（SASP）treating control group（Ⅲ） and traditional Chinese medicine clysters No. 1 group（Ⅳ）. There were 20 rats per group. Trinitrobenzenesulfonic Acid was used to induce the experimental models. The WBC, RBC, platelets of peripheral blood were monitored. The animals are put to death by dislocation in 4, 7, 14 and 21 d after giving the medicine respectively. The pathological changes of the intestines were observed in different times. Result： Compared with group Ⅱ, the counting of platelets of group Ⅳ got rise in seventh day after administration, as of well as the group Ⅲ. There were no statistical differences in WBC and RBC, compared with group Ⅱ after the medicine administration for two weeks. There was no witness in effect of SASP for IBD on rats on organize pathology in this experi- ment. The enema No. 1 lightened pathological injure and promoted the effect of restoration of IBD on rats obviously. Conclusion. The TCM enema No, 1 has anti-IBD activities on inflammatory bowel disease in rats. The foundation is established that the IBD cure on clinic and the basis have been provided the action mechanism of Chinese medicine which is utilized to IBD further.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2005年第21期1677-1681,共5页
China Journal of Chinese Materia Medica
关键词
炎性肠病
溃疡性结肠炎
柳氮磺胺吡啶
inflammatory bowel disease
ulcerative colitis
stdfasalazine
