摘要
应用局部注射高渗ＮａＣｌ与ＰＤＴ联合治疗小鼠前胃癌移植瘤，观察治疗后１，６和２４ｈ的瘤组织形态学变化。结果表明，ＰＤＴ或（和）局部注射高渗Ｎａｃｌ后，均造成瘤细胞膜结构损伤及瘤组织充血、出血、血栓形成等病理改变。其中联合治疗后相应各时间的瘤组织病变程度较单纯治疗组更为明显。提示，肿瘤局部注射高渗Ｎａｃｌ溶液可能主要加重瘤组织微循环障碍和瘤细胞膜性结构损伤两个方面协同ＰＤＴ增强了局部治癌效果。
Transplanted mice forestomach carcinomas were treated by PDT or/and LIHS. The tumorous morphologic changes were observed 1,6,24hours after the treatment.After PDT or/and LIHS, tumorous tissue displayed membranous damage of tumor cells, marked congestion, hemorrhage or thrombosis, etc. In the group of combined treatment, the changes of tumorous tissue were more remarkable. These results suggest that combination of PDT and LIHS can enhance the therapeutic effect of PDT for the carcinoma, and the 2 modalities are synergistic in causing impairment of local microcirculation and damages of membranous structures of the tumor.The synergistic effects were caused by that both modalities interfere with vascularity of the tumor, and alos damage cellular membranes.
出处
《徐州医学院学报》
CAS
1996年第1期49-51,共3页
Acta Academiae Medicinae Xuzhou
关键词
光动力学疗法
氯化钠溶液
肿瘤
形态学
photodynamic therapy,hyperosmotic NaCl solution,tumor morphology.
