摘要
冠心病（ＣＨＤ）在病因、发病年龄等诸多方面存在性别差异。载脂蛋白（ａ）［ａｐｏ（ａ）］多态性与脂蛋白（ａ）［Ｌｐ（ａ）］血浆水平对女性ＣＨＤ影响的资料甚少。我们通过检测３５例女性ＣＨＤ患者和４５例女性正常对照者的ａｐｏ（ａ）多态表型及Ｌｐ（ａ）水平，并与相应的男性组对比分析，发现含有等位基因Ｓ１、Ｓ２、Ｂ的ａｐｏ（ａ）低分子量表型的ＣＨＤ患者，女性占３７．１４％，显著高于对照组，而男性仅占２５．７１％，与对照组比较差异无显著性。在女性中低分子量表型发生ＣＨＤ危险度为对照组的４．７倍，在男性中仅为１．４倍。提示：低分子量表型对女性ＣＨＤ的影响大于男性。Ｌｐ（ａ）水平在两性ＣＨＤ组均明显高于对照组，而两性之间则差异无显著性。
Therearediferencesinthepathogenesisandonsetageofcoronaryheartdisease(CHD)betweentwosexes.Todate,scanty,ifany,datahavebeenpublishedwithregardtoLp(a)andapo(a)polymorphismasriskfactorsforCHDinwomen.Weassessedtheassociationofapo(a)polymorphismandofLp(a)withCHDinChineseHanNationalitybetweentheagesof25to75years.TheCHDpatientsconsistedof67menand35women.Thecontrolsubjectscomprised60menand45womenwhowerefreeofCHD.Apo(a)lowmolecularweightisoformswithB,S1orS2band(associatedwithhigherLp(a)values)weremoreprevalentinfemaleCHDcasesthancontrols(37.14%vs11.1%,P<0.05);butnotinmaleCHDcasesthancontrols.Amongthewomen,thesubjectswithlowmolecularweightisoformshada4.7-foldincreasedriskforCHD;butamongmenonlya1.4-foldincreasedrisk.Lp(a)levelsweresignifcantlyhigherinthepatientsthaninthecon-trolsofbothsexes;butweresimilarinbothsexes.Thisstudysuggestsapo(a)polymorphismassoci-ationswithCHDmaybestrongerinwomenthaninmen.Thepossiblesexdiferencedeservesfurtherexploration.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
1996年第2期107-110,共4页
Chinese Journal of Cardiology
