摘要
本文利用PCR技术检测了44例宫颈癌患者和15例慢性宫颈炎患者病变组织中高危型HPV(16,18,31,33)的感染率,发现44例宫颈癌患者高危型HPV的阳性率高达91%(40/44),其中HPV16型感染率54.55%(24/44),HPV18型感染率18.2%(8/44),HPV31型感染率13.6%(6/44),HPV33型感染率4.55%(2/44);15例慢性宫颈炎患者有2例感染HPV16型。结果提示HPV16型是宫颈癌发生最常见的基因型,其次为HPV18型和HPV31型,故对育龄妇女定期进行高危型HPV感染的普查,在早期预防宫颈癌的发生具有十分重要的意义;联合采用分子生物学和宫颈脱落细胞学技术进行即定期普查,既能提高阳性率,又能对感染高危型HPV的慢性宫颈炎患者进行早期的有效预防。
The infection rates of high- risk human papillomavirus （HPV, typel6, 18, 31, 33） were detected by polymerase chain reaction （PCR） in 44 cervical carcinomas and 15 chronic cervicitis. The results showed that the positive rates of HPV were 91% （40/44）, among which HPV type 16 consisted 54.55% （24/44）, HPV 18 18.2% （8/44）, HPV 31 13.6% （6/ 44） and HPV 33 4.55% （2/44） in 44 cervical carcinomas; while HPV 16 were positive in only 2 of 15 women with chronic cervicitis. The data suggested that the most common prevailing HPV type was HPV 16, and the next HPV 18 and 31. It is necessary for prevention of bervical carcinogenesis early by periodic extensive screening of high- risk HPV for women during childbearing age. Combination application of molecular biological and cervical exfoliocytological techniques is useful for periedical extensive screening of cervix disease, which is not only elevated the positive yields, but also permitted early prevention of cervical carcinogenesis for women infected with high- risk HPV.
出处
《实用预防医学》
CAS
2005年第5期1023-1024,共2页
Practical Preventive Medicine
关键词
宫颈癌
人类乳头状瘤病毒
多聚酶链式反应
Cervical carcinoma
High- risk human papillomaviruses
Polymerase chain reaction
