摘要
目的 通过比较不同程度的主动脉瓣狭窄下游流场均匀性指标以及湍流切应力 (TSS)的差异 ,探讨流场均匀性指标与主动脉瓣狭窄程度的关系 ,及其对手术时机选择的临床应用价值 ;并分析 TSS在病变发展中可能的作用。 方法 对 33例不同程度的主动脉瓣狭窄患者采用脉冲多普勒超声技术 ,于左心室长轴和心尖五腔切面分别测定计算各点的流场均匀性指标以及 TSS。 结果 轻度、中度和重度主动脉瓣狭窄患者间流场均匀性指标最大速度差值 (ΔVmax)和 TSS差别有统计学意义 (P<0 .0 5 ,0 .0 1) ,主动脉瓣越狭窄流场均匀性越差 ,边壁 TSS越小。 结论不同程度的主动脉瓣狭窄之间流场均匀性存在明显的差别 ,其对主动脉瓣狭窄的临床分度及主动脉瓣狭窄患者手术时机的选择具有重要的临床价值。主动脉瓣狭窄程度越重 ,主动脉边壁区的 TSS越小 ,表明低 TSS分布变化在心血管系统狭窄性病变病理过程中可能产生重要作用。
Objective By comparing the difference between different stenosed degree of aortic valve in flow field uniformity and turbulent shear stress （TSS）, to explore the relation between flow field uniformity and different stenosed degree of aortic valve, and probe the clinical value for deciding the operation timing, and analyze the possible role of TSS in the progress of the disease. Methods The flow field uniformity values and TSS in parasternal longaxis plane and apical five-cavity plane on each point were measured and calculated by pulse wave Doppler echocardiography technique for 33 patients with different stenosed degree of aortic valve. Results There were significant difference between the different stenosed degree of aortic valve in maximal velocity difference（ΔVmax）and TSS（P〈0.05, 0.01）. The more severe the aortic stenosis was, the worse the flow field uniformity was, the lower the TSS was. Conclusions There are significant difference between the patients of different stenosed degree of aortic valve in flow field uniformity. Flow field uniformity has important value in classifying the degree of aortic stenosis and deciding the timing of operation. The more severe the aortic stenosis is ,the lower TSS is. It can be thought that low TSS distribution has important role in pathological process of constriction in cardiovascular system diseases.
出处
《中国胸心血管外科临床杂志》
CAS
2005年第1期4-7,共4页
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery
基金
国家自然科学基金资助项目 (3 0 2 70 3 5 8)
CMB综合发展基金资助项目 (96-63 6)~~
关键词
主动脉瓣狭窄
流场均匀性
多普勒超声心动图
湍流切应力
Aortic valve stenosis
Flow field uniformity
Doppler echocardiography
Turbulent shearstress
