摘要
目的:探讨P波离散度(Pd)和血浆脑钠肽水平(BNP)预测老年高血压病患者伴发的阵发性心房颤动的发生。方法:观察34例有阵发性心房颤动的老年高血压病患者(A组,平均年龄70岁)的血浆BNP水平、最大P波时限(Pmax)、最小P波时限(Pmin)、Pd、左房内径(LAD)和左室射血分数(LVEF),并与34例无阵发性心房颤动病史的高血压病患者(B组,平均年龄71岁)比较。结果:血浆BNP水平:A组显著高于B组,(63.75±54.29)ng/L比(32.72±23.37)ng/L,P<0.01;Pd:A组显著高于B组,(69.72±25.04)ms比(28.22±14.15)ms,P<0.001;PmaxA组显著高于B组,(140.02±20.15)ms比(110.35±18.83)ms,P<0.001;LVEF:A组显著低于B组,(61.84±9.01)%比(67.72±5.18)%,P<0.05;Pmin、LAD两组差别无统计学差异。结论:血浆BNP水平和Pd均能预测老年高血压病患者伴发的阵发性心房颤动的发生。
Objective： To explore whether the risk of paroxysmal atrial fibrillation（PAF） of old patients with essential hypertension could be identified by plasma levels of brain natriuretic peptide （BNP） or left atrial dispersion （Pd）.Methods： The plasma levels of brain natriuretic peptide（BNP）,the maximum of P wave duration （Pmax）, the minimum of P wave duration （Pmin）,and the P wave dispersion （Pd = Pmax-Pmin）from the 12-leads surface electrocardiogram of 34 old essential hypertensive patients with history of PAF （group A,mean age 70） and 34 elderly essential hypertensive patients without history of PAF （group B ,mean age 71）, and left ventricular ejection fraction （LVEF） were measured by echocardiogryphy,Results：Plasma levels of BNP,Pmax and Pd were significantly higher in group A than those in group B （ BNP,67.35 ± 54.29 ng/dl vs 32.72± 23.37 ng/dl, P 〈 0.01 ;Pmax, 140.02 ±20,15 ms vs 110.35± 18,83 ms,P〈 0.001 ; Pd,69.72±25.04 ms vs 28.22±14.15 ms, P〈 0.001）; LVEF was significanty lower in group A than that in group B[（61.84 ± 9.01）% vs （67.72± 5.18）%, P 〈 0.05 ].Conclusion： Plasma levels of BNP and Pd may be usded for the prediction of the risk of developing PAF in old essential hypertensive patients.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2005年第11期817-818,826,共3页
Journal of Nanjing Medical University(Natural Sciences)
关键词
心房颤动
脑钠肽
P波离散度
高血压
老年
paroxysmal atrial fibrillation
brain natriuretic peptide
P wave dispersion
old hypertension
