摘要
目的探讨总摄氟量与儿童龋齿间的剂量-反应关系。方法选择江苏省泗洪县瓦庙村(地方性氟中毒重病区村,饮水含氟0.57～4.50mg/L)和新淮村(非地方性氟中毒病区村,饮水含氟0.18～0.76mg/L)所有在校的8～13岁小学生为对象,调查学生龋齿患病率、学生家庭饮水含氟量、各种食物的摄入量、饮水量以及总摄氟量。根据人均总摄氟量将儿童分为不同的接触组,即<1.00、1.00￣、1.50￣、2.00￣、2.50￣、3.00￣、3.50￣及≥4.00mg/d共8组,分别统计各组儿童的龋齿患病率和龋均。结果当总摄氟量较低时,随着总摄氟量的增加,儿童龋齿患病率和龋均逐渐降低;当总摄氟量超过3.32mg/d时,儿童龋齿患病率和龋均逐渐升高。总摄氟量和儿童龋齿患病率及龋均间呈一U型的剂量-反应关系。按此剂量-反应关系计算的总摄氟量的95%可信限下限(BMDL)分别为3.49和3.15mg/d。由此推算出的总摄氟量的参考剂量(RfD)为3.49和3.15mg/d。结论由总摄氟量和龋齿的剂量-反应关系计算的总摄氟量的参考剂量远远大于中国人群总摄氟量的国家卫生标准。
Objective Study on the relationships between the daily total intake of fluoride and children＇s dental caries. Methods The primary school students aged 8 - 13 years old,in Wamiao village （a severe endemic fluorosis area,its levels of fluoride in drinking water being 0.57 - 4.50 mg/L） and Xinhuai village （a non-endemic fluorosis area,its levels of fluoride in drinking water being 0.18 - 0.76 mg/L） were recruited in this study. Epidemiological methods were used to investigate the children＇s dental caries,the levels of fluoride in students＇ household well, daily intake of various food and drinking water and daily total intake of fluoride. The students were divided into 8 groups according to the daily total intake of fluoride per person,which were 〈 1.00, 1.00 -, 1.50 -,2.00 -, 2.50 -,3.00 -,3.50 - and ≥4.00 mg/d ;the prevalence of dental caries and the decayed,missing and filled teeth （DMFT）in each group were calculated respectively. Results As the daily total fluoride intake increased, the prevalence of caries and DMFT were reduced gradually when the daily total intake of fluoride was below 3.32 mg/d,but the relationship was positive when the daily total intake of fluoride was over 3.32 mg/d. Thus the dose- response relationship between the daily total intake of fluoride and the prevalence of dental caries existed in a U-shape. The lower-bound confidence limit on benchmark dose （BMDL） was calculated to be 3.49 and 3.15 mg/d respectively, according to this U-shape dose-response relationship. The reference dose （RID） of daily total intake was calculated to be 3.49 and 3.15 mg/d. Conclusions The RID of daily total intake of fluoride,calculated according to the dose-response relationships between the daily total intake of fluoride and the prevalence of dental caries, were much higher than the hygienic standard for daily total intake fluoride（WS/T 87-1996）.
出处
《中国地方病学杂志》
CAS
CSCD
北大核心
2005年第6期655-658,共4页
Chinese Jouranl of Endemiology
基金
江苏省人民政府和国土资源部资助项目(200312300008)
江苏省地方病防治协会资助项目(X200327)
关键词
氟
龋齿
剂量效应关系
Fluorine
Dental caries
Dose-response relationship
