摘要
目的探讨弹力纤维、Ⅳ型胶原、CD44v6表达与肺腺癌转移的相关性。方法应用弹力纤维染色、免疫组织化学方法观察56例肺腺癌,了解弹力纤维、Ⅳ型胶原、CD44v6的表达状况,分析其与肺腺癌转移的关系。结果弹力纤维、Ⅳ型胶原、CD44v6表达在有、无淋巴结转移组中皆有显著差异(P=0.000);并与淋巴结有否转移显著相关(r=-0.581、0.476、0.635;P<0.01)。结论弹力纤维、Ⅳ型胶原、CD44v6表达与肺腺癌转移密切相关,对其检测有助于对肺腺癌转移及预后做出判断。
Objective To study the expression of elastic fibers, Collagen type Ⅳ and CD44v6 in the metastasis of the pulmonary Methods In paraffin-embedded specimens from 56 cases of pulmonary adenocarcinoma, the elastic fibers were stained with histochemical method and the expressions of collagen type IV and CD44v6 were detected with immunohistochemical method. Results The positive expression rates of elastic fibers, collagen type IV and CD44v6 were 11.5% （3/26）, 11. 5% （3/26） and 80. 8% （21/26）in the group with lymph node metastasis, and were 69. 0% （20/29）, 55.2% （16/29） and 24. 1% （7/29） in the group without lymph node metastasis, respectively. The expression of elastic fibers, collagen type Ⅳ and CD44v6 were significant difference in the two groups with and without lymph node metastasis （ P=0. 000）. There was statistically significant correlation among elastic fibers, collagen type IV, CD44v6 and lymph node metastasis （ all P〈0.01 ）. Conclusion There is significant correlation among elastic fibers, collagen type Ⅳ, CD44v6 and lymph node metastasis. Detection of elastic fibers, collagen type IV and CD44v6 may be used as predictors of the metastasis and prognosis of pulmonary adenocarcinoma.
出处
《中国医师杂志》
CAS
2005年第11期1478-1480,共3页
Journal of Chinese Physician
关键词
弹力纤维
Ⅳ型胶原
CD44V6
肺腺癌
Adenocarcinoma
Pulmonary
Elastic fibers
Collagen type Ⅳ
CD44v6
Metastasis
