摘要
目的:研究姜黄素对动脉粥样硬化(AS)内皮细胞损伤的保护作用。方法:复制实验性大鼠AS模型,测定超氧化物歧化酶(SOD)活性和丙二醛(MDA)、前列环素(PG I2)、血栓素A2(TXA2)含量。采用免疫组化、RT-PCR方法检测AS斑块细胞间粘附分子-1(ICAM-1)和ICAM-1mRNA的表达水平。结果:姜黄素可使血清MDA及血浆TXB2(TXA2)含量降低,6-酮-前列腺素F1 a(PG I2)升高,并使AS斑块ICAM-1表达水平降低。结论:姜黄素抗AS作用的机制可能与其抗氧化、抗血栓及抗粘附作用等保护血管内皮细胞功能密切相关。
Objective： To investigate the protective effect of total curcumin to the damage of atheromatous endothelial cell. Method： The experimental atheromatous model of SD rat was duplicated; the activity of maleic dialdehyde （MDA） and the content of superoxide dismutase （SOD）, prostacyclin （PGI2） and thromboxane A2 （TXA2） were assayed. Immunohistochemical method was adopted to measure the intercellular adhesion molecule 1 （ICAM-1） in atheromatous plaque, and the expression of ICAM-1 mRNA were detected by RT-PCR. Results： Curcumin can reduce blood serum MDA, the content of plasm TXA2; raise the content of PGT2. The expression of ICAM-1 was reduced. Conclusion ： The mechanism of curcumin anti-atherosclerosis probably due to the function of protecting angio-endothelial cell, anti-oxidation, anti-thrombus and anti-adhesiveness.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2005年第5期10-12,共3页
Pharmacology and Clinics of Chinese Materia Medica
