摘要
目的:研究苦豆子总碱对60Coγ射线照射雄性小鼠生殖细胞的影响。方法:小鼠腹腔注射苦豆子总碱,采用60Coγ射线全身均匀照射,剂量为5.0Gy,检测受照小鼠染色体畸变率、精子畸形率、睾丸指数以及对其睾丸组织进行病理学观察。结果:辐射损伤后小鼠染色体畸变率、精子畸形率增加,睾丸指数下降并发生形态学改变。苦豆子总碱可促进上述受损指标的恢复。结论:苦豆子总碱对受照小鼠雄性生殖细胞具有一定的保护作用。
Objective： To study the protective effect of tatal alkaloids from Sophora alopecuroides （TASA） on the radiative damage of male reproductive cells. Methods： The mice were treated ip in the different doses of TASA, which were exposed to whole-body ^60Coy-rays at the dose of 5.0 Gy. Then chromosome aberration of testicular cells, spermatozoa deformity, testicle/body weight were measured; histopathology were observed. Results： After radiation injury, rates of testicular cells chromosome aberration and spermatozoa deformity were increased obviously, testicle/body weight reduced, testicular histopathology changed remarkablely. TASA administration ip can accelerate restoration of the indexs. Conclusion： TASA has certain protective effects on irradiated mice.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2005年第5期19-20,共2页
Pharmacology and Clinics of Chinese Materia Medica
关键词
苦豆子总碱
染色体畸变
精子畸形
辐射损伤
Sophora alopecuroides
chromosome aberration
spermatozoa deformity
radiation injure
