摘要
目的:骨形态发生蛋白在骨骼疾病的预防和治疗方面具有重要作用,近来对绵羊多产FecB基因分子机制的研究,表明骨形态发生蛋白及其受体对动物卵泡发育具有重要影响,阐述不同种类骨形态发生蛋白及其受体对卵泡发育的影响,进而探索有效的调控动物生殖的手段。资料来源:应用计算机检索Medline数据库1998-01/2005-06期间的相关文献,检索词为“BMP”和“BMPR”,分别组合进行检索,限定文章语言种类为英文。同时计算机检索中国期刊全文数据库、万方数据库1996-01/2005-10期间的相关文献,检索词为“BMP,BMPR”,骨形态发生蛋白”,限定文章语言种类为中文。资料选择:对资料进行初审,选取有关骨形态发生蛋白及其受体方面的有关文献共200篇,中文140篇,英文60篇。资料提炼:按照骨形态发生蛋白特点及其受体对卵泡发育及生殖内分泌的影响进行筛选,30篇文献纳入标准。资料综合:30篇文献中有18篇关于骨形态发生蛋白及其受体功能以及信号转导机制研究的文献,12篇关于不同骨形态发生蛋白对于生殖细胞分泌及受体突变对于排卵数影响的文献。结论:骨形态发生蛋白家族在动物生殖调控中具有重要作用,现有的实验证明骨形态发生蛋白受体基因突变导致的信号转导过程的改变对于阐明绵羊多胎机制具有一定突破。对于卵泡发育调控和排卵机制的研究有利于为绵羊或其他物种的多胎调控提供理论参考。
OBJECTIVE：Bone morphogenetic protein （BMP） plays a vital role in the prevention and treatment of skeleton diseases, recently researches on the molecular mechanism of sheep prolific FecB gene indicated that BMP and its receptors have important influence on animal follicular development. In this study the influence of different type BMPs andits receptors on the follicular development was reviewed in order to explore effective modulation on animal reproduction.DATA SOURCES： Computer was applied to retrieve Medline database on the related literatures from January 1998 to June 2005. The retrieval words were ＂BMP＂ and ＂BMPR＂ that combined respectively. Language in the articles was limited to English. Simultaneously related articles were also computer searched in China periodical full text database and Wanfang databases from January 1996 to December 2005 with the retrieval words of ＂BMP, BMPR＂, that limiting the article language to Chinese.STUDY SELECTION： At first, the document was retrieved, altogether 200 studies on BMP and its receptors were enrolled including 140 Chinese literatures and 60 English literatures.DATA EXTRACTION： these literatures were screened and 30 were included for relating to the BMP characteristic, as well as the influence of BMP and its receptors on follicular development and reproductive endocrine.DATA SYNTHESIS： Of the 30 literatures, 18 experiments discussed the function of BMP and its receptors and its signal transduction mechanism,12 were about the influence of different BMP on reproductive cell secretion, as well as receptor mutation on ovulation.CONCLUSION： BMPs family plays vital role in animal reproductive modulation, current experiments prove that the changes of signal transduction due to BMP receptor gene mutation has made breakthrough for the exploration of the prolific mechanism in sheep. Moreover studies on follicular development modulation and ovulation mechanism are liable to provide theoretical reference for the prolific modulation in sheep or other species.
出处
《中国临床康复》
CSCD
北大核心
2005年第42期190-192,共3页
Chinese Journal of Clinical Rehabilitation
基金
上海市科技兴农重点攻关项目[农科攻字(2002)第1-3-6号]~~
