摘要
【目的】观察铝镁加混悬液对胆汁反流性胃炎的临床疗效及对胃内24 h胆汁的影响。【方法】经胃镜和胃内24 h胆汁监测确诊的胆汁反流性胃炎46例,随机分为治疗组24例,服用铝镁加混悬液和莫沙必利;对照组22例,单用莫沙比利。疗程均为4周,观察腹痛、腹胀、呕吐胆汁等症状变化,治疗结束后复查胃镜和胃内24 h胆汁监测。【结果】治疗后两组患者症状均有明显改善,总有效率分别为95.83%和81.82%,无显著差异(P>0.05);但治愈率分别为54.17%和22.73%,差异显著(P<0.05)。治疗前后两组患者24 h胃内胆汁反流总时间百分比均有明显下降(P<0.01),两组间变化率也有显著差异(P<0.05)。【结论】铝镁加混悬液可有效的结合胃内胆汁,与莫沙必利联用对治疗胆汁反流性胃炎效果显著。
[Objective]To observe the clinical effect of Almagate suspension on bile-reflux gastritis and the influence on 24-hour intragastric bile. [Methods]Forty-six patients with bile-reflux gastritis proven by endoscopic examination and 24-hour intragastric bile monitoring were divided into 2 groups at random. Treatment group （ n =24） took Almagate suspension and mosapride citrate tablets, the control group（ n =22） took mosapride only. The severity of all the symptoms including abdominal pain,abdominal distention, nausea and bile vomitus were investigated four weeks after treatment. Endoscopic examination and 24-hour intragastric bile monitoring were reexamined after treatment. [Results]All the symptoms in the two groups improved greatly. The efficient rates were 95.83% in treatment group and 81.82% in contral group,There were no significant differences between them（ P〉0.05）. But the cure rates were 54.17% and 27.27% respectively , there were significant differences between them（ P〈0. 05）. The total time percentage of 24-hour intragastric bile-reflux had both greatly decreased after treatment（ P 〈0. 01）. The two groups variety rates had significant differences （ P〈0.05）. [Conclusion]Almagate Suspension can bind with intragastric bile efficiently. When it and mosapride citrate tablets are used to treat bile-reflux gastritis, there will be significant effect.
出处
《医学临床研究》
CAS
2005年第11期1591-1592,1597,共3页
Journal of Clinical Research
