摘要
本文通过文献综述,对动物线粒体DNA控制区进行了阐述。从线粒体控制区(control region)基因组的研究出发,重点介绍了动物线粒体控制区基因组结构特点。主要结论:由于碱基替换、插入和缺失以及重复序列数目的变异致使D-loop成为mtDNA中变异最多的区域,但突变和结构重排并不是发生在整个D-loop区域,而是在高变区;大多研究集中在mtDNA D-loop保守区和异质方面:对D-loop序列分析,能较好地阐明动物的起源,在动物亲缘关系鉴定、系统进化和物种形成方式的研究等领域具有广阔的研究和应用前景。
In this paper, the mitochondrial DNA control region （D lcop） was reviewed. In terms of nucleotide substitutions, short insertions/deletions （indels）, and dynamics of variable-number tandem repeats （VNTRs）, D-loop are usually considered to be the most variable parts of mtDNAs. However, site mutability and structural rearrangements are not distributed randomly acro^s the entire region, but affect particular hypervariable sites and domains. The research of mitochondrial DNA genome of D-loop focus on conserved domain and heteroplasmy contributed to nucleotide variance and number variation that altered in mitochondrial DNA hypervariable region. Most of the analysis of D-loop sequences can aid in researching the origin of animal, the animal genetic relationship identification, analysis of population variance, evolution, individual or cell recognization, and species way.
出处
《四川动物》
CSCD
北大核心
2005年第4期669-672,共4页
Sichuan Journal of Zoology
