摘要
在微波辐射下以芳醛、1,3-环己二酮或达米酮和氨基吡唑为原料,用乙二醇作能量转移剂,三组分“一锅法”快速合成了一系列吡唑[5,4-b]并喹啉类化合物.该方法速度快(30~90s),产率高(88%~98%),环境友好.产物结构通过红外光谱、核磁共振谱和元素分析证实,化合物4e的单晶经X射线衍射分析,进一步确证了产物结构.
A series of 5-aryl-1,5,6,7,8,9-hexahydro-2H-pyrazolo[5,4-b]quinolin-6-one dervatives were synthesized by the three component one-pot reaction of 5-amino-3-methyl-l-phenypyrazole with aromatic aldehydes and dimedone or 1,3-cyclohexanedione under microwave irradiation using glycol as energy trans- fer agent. This method has the advantage of excellent yields (88%~98%), short reaction time (30~90 s) and being environmental friendliness. The structures of the products were identified by IR, NMR spectra, elemental analysis and X-ray crystallograghic of 4e.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2005年第12期1610-1614,共5页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.20372057)
江苏省苏州大学化学及化学工程有机合成重点实验室开放基金(No.S81009111)
江苏省药用植物生物技术重点实验室基金(No.01AXL14)资助项目
关键词
吡唑并喹啉
氨基吡唑
微波辐射
pyrazolo[5,4-b]quinoline
aminopyrazole
microwave irradiation