期刊文献+

微波辐射下三组分“一锅法”合成5-芳基-1,5,6,7,8,9-六氢化-2H-吡唑[5,4-b]并喹啉-6-酮 被引量:3

Facile Three Component One-pot Synthesis of 5-Aryl-1,5,6,7,8,9-hexahydro-2H-pyrazolo[5,4-b]quinolin-6-one Derivatives under Microwave Irradiation
下载PDF
导出
摘要 在微波辐射下以芳醛、1,3-环己二酮或达米酮和氨基吡唑为原料,用乙二醇作能量转移剂,三组分“一锅法”快速合成了一系列吡唑[5,4-b]并喹啉类化合物.该方法速度快(30~90s),产率高(88%~98%),环境友好.产物结构通过红外光谱、核磁共振谱和元素分析证实,化合物4e的单晶经X射线衍射分析,进一步确证了产物结构. A series of 5-aryl-1,5,6,7,8,9-hexahydro-2H-pyrazolo[5,4-b]quinolin-6-one dervatives were synthesized by the three component one-pot reaction of 5-amino-3-methyl-l-phenypyrazole with aromatic aldehydes and dimedone or 1,3-cyclohexanedione under microwave irradiation using glycol as energy trans- fer agent. This method has the advantage of excellent yields (88%~98%), short reaction time (30~90 s) and being environmental friendliness. The structures of the products were identified by IR, NMR spectra, elemental analysis and X-ray crystallograghic of 4e.
出处 《有机化学》 SCIE CAS CSCD 北大核心 2005年第12期1610-1614,共5页 Chinese Journal of Organic Chemistry
基金 国家自然科学基金(No.20372057) 江苏省苏州大学化学及化学工程有机合成重点实验室开放基金(No.S81009111) 江苏省药用植物生物技术重点实验室基金(No.01AXL14)资助项目
关键词 吡唑并喹啉 氨基吡唑 微波辐射 pyrazolo[5,4-b]quinoline aminopyrazole microwave irradiation
  • 相关文献

参考文献22

  • 1Farghaly, A. M, Habib, N. S, Khalil, M. A, El-Sayed, O. A,Alexandria J. Pharm. Sci. 1989, 3(1), 90.
  • 2Bristol-Meyers, Co. FR 2149275, 1973 [Chem. Abstr. 1973,79, 78784n].
  • 3Simrnoff, P, Crenshaw, R. R. Antimicrob. Agents Chemother. 1977, 11,571.
  • 4Stein, R. G, Beil, J. H, Singh, T. J. Med. Chem. 1970, 13,153.
  • 5Bell, M. R., Ackerman, J. H. US 4920128, 1990 [Chem.Abstr. 1990, 113, 172015].
  • 6Bossert, F, Vater, W. Med. Res. Rev. 1989, 9, 291.
  • 7Musierowica, A, NIementowski, S, Tomasik, Z. Rocz.Chem. 1928, 8, 325.
  • 8Paul, S, Gupta, M, Gupta, R, Loupy, A. Tetrahedron Lett.2001, 42, 3827.
  • 9Quiroga, J, Insuasty, B, Foces-Foces, C, Infates, L,Claramunt, R. M, Cabildo, P, Jiménez, J. A, Elguero, J.Tetrahedron 1997, 53(31), 10783.
  • 10Quiroga, J, Insuasty, B, Saitz, C, Jullian, C. J. Heterocycl.Chem. 1998, 35, 575.

二级参考文献2

  • 1Sainani J B,Indian J Chem.B,1994年,33卷,526页
  • 2Zhang X Y,离子交换与吸附,1999年,15卷,374页

共引文献24

同被引文献53

引证文献3

二级引证文献12

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部