摘要
以天然聚合物壳聚糖为原料,在其2-NH2上引入具有温度敏感的基团聚(N-异丙基丙烯酰胺),制得了新型的N-取代聚(N-异丙基丙烯酰胺)壳聚糖。通过FT-IR1、3C-NM R1、H-NM R对其结构进行表征;用粉末X射线衍射、差示扫描量热法对其物理性质进行了分析。
The reverse thermo-responsive drug delivery systems can be changed their physicochemical properties in response to variations of surroundings. Polymer （N-isopropyl acrylamide） （PNIPAAm） is known to be a kind of thermally responsive material and has a lower critical solution temperature （LCST, 32℃） at which a macromolecular transition from a hydrophilic to a hydrophobic structure occurs. Chitosan is a useful natural polymeric biomaterial due to its biocom patibility and biodegradable properties. The goal of this research was developed to prepare thermo-sensitive PNIPAAm-chitosan as a drug vehicle for the ophthalmic. The grafted copolymer was synthesized by using PNIPAAm group introduced into the amino group of chitosan and characterized by FT-IR, ^1H-NMR and ^13C-NMR. And WAXD and DSC were used to measure some of its physical properties.
出处
《高分子材料科学与工程》
EI
CAS
CSCD
北大核心
2005年第6期236-239,共4页
Polymer Materials Science & Engineering
基金
国家自然科学基金(30271554)
教育部科技研究重点项目基金(03090)资助课题
关键词
壳聚糖
聚(N-异丙基丙烯酰胺)
温度敏感
制备
表征
chitosan
poly（N-isopropyl acrylamide）
t hermo-responsive
preparation
characterization
