摘要
目的:探讨3种硝基咪唑类药物治疗方案用于滴虫性阴道炎的疗效、不良反应及成本-效果。方法:将111例患者随机分成3组,分别给予甲硝唑(A组)、替硝唑(B组)和奥硝唑(C组)治疗,观察各组疗效及不良反应,并进行成本-效果分析。结果:A、B、C组药物的成本依次为0.74元、33.6元、41.2元;治愈率分别为59.4%、81.6%、97.2%;成本-效果比分别为0.01、0.41、0.42;B、C组相对于A组的增量成本-效果比分别为1.48、1.07;不良反应发生率分别为62.2%、18.4%、11.1%。结论:C方案为滴虫性阴道炎的较佳治疗方案。
OBJECTIVE：To discuss the curative effects,adverse drug reactions（ADRs）and cost-effectiveness of 3 kinds of nitroimidazole drugs for treatment of trichomonal vaginitis. METHODS： 111 cases of trichomonal vaginitis were randomly divided into 3 groups, administered with metronidazol（group A ）, tinidazole （group B ）, and ornidazol （group C） respectively, the curative effects and ADRs were observed and cost- effectiveness analysis was made in all groups. RESULTS：The costs in 3 groups were 0.74 yuan, 33.6 yuan and 41.2 yuan respectively. The cure rates were 59.4%, 81.6% and 97.2 %, respectively. The cost - effectiveness ratios were 0.01, 0.41, and 0.42 respectively. The increment cost - effectiveness ratios in group B and C were 1.48 and 1.07, as compared with group A. The occurrences of ADRs were 62.2%, 18.4%, andll.l% respectively. CONCLUSION：Among 3 regimes, regime C is the preferred one.
出处
《中国药房》
CAS
CSCD
北大核心
2005年第22期1716-1718,共3页
China Pharmacy
关键词
滴虫性阴道炎
治疗方案
成本-效果分析
Trichomonal vaginitis
Therapeutic regime
Cost - effectiveness analysis
